Notch pathway components in serial sections of the human colon.

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Notch pathway components in serial sections of the human colon. Notch pathway components in serial sections of the human colon. (A) PAS staining for goblet cells (pink) in crypt structures of the colon. (B) NICD staining (brown) occurs in virtually all epithelial nuclei, indicative of active Notch signaling. Note the negative (blue) nuclei of stromal cells. (C) HES1 staining (brown) occurs in the nuclei of most cells in the colon, indicative of active Notch signaling. (D) ATOH1 staining (brown) reveals that a minority of differentiated cells express this goblet cell marker in the colon. Note that ATOH1 is repressed by active Notch signaling. Vivianda Menke et al. Dis. Model. Mech. 2010;3:104-110 ©2010 by The Company of Biologists Limited