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Inducible DM1 model displays increased autophagy.

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Presentation on theme: "Inducible DM1 model displays increased autophagy."— Presentation transcript:

1 Inducible DM1 model displays increased autophagy.
Inducible DM1 model displays increased autophagy. (A,B) Fluorescent confocal images of LysoTracker staining (red) indicate increased puncta formation in model flies [hs-Gal4 UAS-i(CTG)480>UAS-GFP; B] when compared to controls (hs-Gal4>UAS-GFP UAS-GFP; A). Nuclei were counterstained with Hoechst (C-F) Fluorescent confocal images of immunodetection of the GFP reporter (green) in two transgenic fly lines expressing GFP:Atg8a show strong punctate staining in model flies [hs-Gal4 UAS-i(CTG)480>UAS-GFP:Atg8a; D,F] when compared to counterpart controls (hs-Gal4>UAS-GFP:Atg8a; C), indicating increased autophagic activity in model flies. Nuclei were counterstained with DAPI. (G) Western blot of protein extracts of flies with the genotypes in C-F with the indicated antibodies. Ariadna Bargiela et al. Dis. Model. Mech. 2015;8: © Published by The Company of Biologists Ltd

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