Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease Nan Zhang, MD, PhD, Thibaut Van Zele, MD, PhD, Claudina.

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Presentation transcript:

Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease Nan Zhang, MD, PhD, Thibaut Van Zele, MD, PhD, Claudina Perez-Novo, PhD, Nicholas Van Bruaene, MD, Gabriele Holtappels, Natalie DeRuyck, Paul Van Cauwenberge, MD, PhD, Claus Bachert, MD, PhD Journal of Allergy and Clinical Immunology Volume 122, Issue 5, Pages 961-968 (November 2008) DOI: 10.1016/j.jaci.2008.07.008 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Semiquantitative evaluation of granulocyte tissue infiltration. Values are reported as medians and interquartile ranges for each group. The significance level was set at an α value of .05. Concentrations for ECP and MPO are reported as medians and interquartile ranges for each group, and the significance level equals a P value of .05. From these data, an ECP/MPO ratio was calculated. HE, Hematoxylin. Journal of Allergy and Clinical Immunology 2008 122, 961-968DOI: (10.1016/j.jaci.2008.07.008) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 mRNA levels for T-bet, GATA-3, RORC, and Foxp3 transcription factors normalized to the levels of β-actin, hydroxymethylbilane synthase, and elongation factor 1 as housekeeping genes in each group. Values are reported as medians and interquartile ranges for each group. The significance level was set at a P value of .05. Journal of Allergy and Clinical Immunology 2008 122, 961-968DOI: (10.1016/j.jaci.2008.07.008) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Concentrations of soluble IL-2 receptor α (sIL-2Rα), IL-5, IFN-γ, IL-1β, IL-6, IL-17A, eotaxin, IgE, and TGF-β1 protein in each group. Values are reported as medians and interquartile ranges for each group. The significance level was set at a P value of .05. Please note that the TGF-β1 protein data refer to patients without asthma (see the Results section). Journal of Allergy and Clinical Immunology 2008 122, 961-968DOI: (10.1016/j.jaci.2008.07.008) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions