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The Editors' Choice Journal of Allergy and Clinical Immunology

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Presentation on theme: "The Editors' Choice Journal of Allergy and Clinical Immunology"— Presentation transcript:

1 The Editors' Choice Journal of Allergy and Clinical Immunology
Donald Y.M. Leung, MD, PhD, Stanley J. Szefler, MD  Journal of Allergy and Clinical Immunology  Volume 125, Issue 1, Pages (January 2010) DOI: /j.jaci Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Primary end points: relative differences between treatment groups and corresponding P values.
Journal of Allergy and Clinical Immunology  , 98-99DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Pattern of component recognition between subjects with peanut allergy (yellow) and peanut-tolerant subjects (green). Ara h 2 offers best discrimination. Journal of Allergy and Clinical Immunology  , 98-99DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Plasticity of TH17 cells. Human TH17 cells, which express retinoic acid receptor–related orphan receptor C (RORC), T-box transcription factor (T-bet), IL-12Rβ2, IL-4Rα, CD161, and CCR6 in the presence of IL-12 produced by dendritic cells, exhibit upregulation of T-bet expression, acquire CXCR3 on their surface, and shift to the production of IFN-γ (TH17/TH1 and TH1 cells), as has recently been shown even in mice. In the presence of IL-4, which can be produced by TH2 cells, basophils, and mast cells, human TH17 cells upregulate GATA-3 and shift to the production of IL-4 (TH17/TH2 cells). Journal of Allergy and Clinical Immunology  , 98-99DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Copriming moDCs from a subject with cat allergy with H22–Fel d 1 and TSLP provides a potent TH2 stimulus compared with priming with non–receptor-targeted Fel d 1 (Fel), H22–Fel d 1 (H-Fel), or TSLP alone. Journal of Allergy and Clinical Immunology  , 98-99DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 FOXP 3 expression in the thymus and lymph nodes of patients with OS.
Journal of Allergy and Clinical Immunology  , 98-99DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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