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Volume 2, Issue 4, Pages 305-313 (April 2015) Effects of cognitive behaviour therapy for worry on persecutory delusions in patients with psychosis (WIT): a parallel, single-blind, randomised controlled trial with a mediation analysis Prof Daniel Freeman, PhD, Prof Graham Dunn, PhD, Helen Startup, DPhil, Katherine Pugh, DClinPsy, Jacinta Cordwell, DClinPsy, Helen Mander, DClinPsy, Emma Černis, MSc, Gail Wingham, BSc, Katherine Shirvell, MSc, Prof David Kingdon, MD The Lancet Psychiatry Volume 2, Issue 4, Pages 305-313 (April 2015) DOI: 10.1016/S2215-0366(15)00039-5 Copyright © 2015 Freeman et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 1 Trial profile PSWQ=Penn State Worry Questionnaire. CBT=cognitive behavioural therapy. The Lancet Psychiatry 2015 2, 305-313DOI: (10.1016/S2215-0366(15)00039-5) Copyright © 2015 Freeman et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 2 Mediation analysis Rectangles or squares represent measured variables. Ellipses or circles represent latent variables (including random errors or residuals). Single headed arrows represent predisposing effects; bold arrows represent main ones of interest. Double-headed arrows represent correlations. W8=worry measures at 8 weeks. W24=worry measures at 24 weeks. D8=delusion measures at 8 weeks. D24=delusion measures at 24 weeks. e1 and e2=random residuals (worry). e3 and e4=random residuals (delusions). The Lancet Psychiatry 2015 2, 305-313DOI: (10.1016/S2215-0366(15)00039-5) Copyright © 2015 Freeman et al. Open Access article distributed under the terms of CC BY Terms and Conditions