Adjunctive Therapies in the Treatment of Acute Coronary Syndromes Wayne L. Miller, MD, PHD, Guy S. Reeder, MD Mayo Clinic Proceedings Volume 76, Issue 4, Pages 391-405 (April 2001) DOI: 10.4065/76.4.391 Copyright © 2001 Mayo Foundation for Medical Education and Research Terms and Conditions
Figure 1 Trend in β-blocker therapy use after myocardial infarction based on data from the Worcester Heart Attack Study (adapted with permission from McCormick et al42). Mayo Clinic Proceedings 2001 76, 391-405DOI: (10.4065/76.4.391) Copyright © 2001 Mayo Foundation for Medical Education and Research Terms and Conditions
Figure 2 β-Blocker therapy in the elderly based on data from the New Jersey Community Post-MI Study, 1987–1992. MI = myocardial infarction (adapted with permission from Soumerai et al43). Mayo Clinic Proceedings 2001 76, 391-405DOI: (10.4065/76.4.391) Copyright © 2001 Mayo Foundation for Medical Education and Research Terms and Conditions
Figure 3 Effect of nitrate therapy on short-term mortality after acute myocardial infarction. CEI = converting enzyme inhibitors; CI = confidence interval; IV = intravenous; N = nitrate (adapted with permission from ISIS-4 Collaborative Group45). Mayo Clinic Proceedings 2001 76, 391-405DOI: (10.4065/76.4.391) Copyright © 2001 Mayo Foundation for Medical Education and Research Terms and Conditions
Figure 4 Angiotensin-converting enzyme inhibitor (ACE-I) therapy in 30-day mortality after myocardial infarction. CI = confidence interval; O - E = observed minus expected (adapted with permission from the ISIS-4 Collaborative Group45). Mayo Clinic Proceedings 2001 76, 391-405DOI: (10.4065/76.4.391) Copyright © 2001 Mayo Foundation for Medical Education and Research Terms and Conditions
Figure 5 Effect of angiotensin-converting enzyme inhibitor therapy on sudden cardiac death based on a meta-analysis that included 15,104 patients (adapted with permission from Domanski et al52). Mayo Clinic Proceedings 2001 76, 391-405DOI: (10.4065/76.4.391) Copyright © 2001 Mayo Foundation for Medical Education and Research Terms and Conditions
Figure 6 Amiodarone therapy after acute myocardial infarction based on meta-analysis of 6500 patients. CI = confidence interval (adapted with permission from Amiodarone Trials Meta-Analysis Investigators65). Mayo Clinic Proceedings 2001 76, 391-405DOI: (10.4065/76.4.391) Copyright © 2001 Mayo Foundation for Medical Education and Research Terms and Conditions
Figure 7 4S survival trial data in patients with angina after myocardial infarction (left ventricular dysfunction excluded) (adapted with permission from Scandinavian Simvastatin Survival Study Group68). Mayo Clinic Proceedings 2001 76, 391-405DOI: (10.4065/76.4.391) Copyright © 2001 Mayo Foundation for Medical Education and Research Terms and Conditions
Figure 8 Effect of intravenous magnesium therapy on short-term mortality after acute myocardial infarction based on randomized trial data. CI = confidence interval; NS = not significant (adapted with permission from ISIS-4 Collaborative Group45). Mayo Clinic Proceedings 2001 76, 391-405DOI: (10.4065/76.4.391) Copyright © 2001 Mayo Foundation for Medical Education and Research Terms and Conditions
Figure 9 Effect of estrogen/progestin on nonfatal myocardial infarction. CAD = coronary artery disease (adapted with permission from Hulley et al81). Mayo Clinic Proceedings 2001 76, 391-405DOI: (10.4065/76.4.391) Copyright © 2001 Mayo Foundation for Medical Education and Research Terms and Conditions