Endocytic and biosynthetic-secretory pathways

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Presentation transcript:

Endocytic and biosynthetic-secretory pathways (Ten or more chemically distinct, membrane-enclosed compartments) Transport vesicles

The biosynthetic-secretory and endocytic pathways

Various types of coated vesicles Golgi apparatus Plasma ER and Golgi Cisternae

Assembly of a clathrin coat Coated pits and vesicles on the cytosolic surface of membranes 36 triskelions 12 pentagons 6 hexagons triskelion Inner layer binds adaptins Freeze-etch

GTPases function in vesicle formation GAP = GTPase Activating Protein GEF = Guanine Nucleotide Exchange Factor

Dynamin pinches of the vesicles GTPase Shibire mutant has coated pits but no budding off of synaptic vesicles

The entry of enveloped viruses into cells HIV Similar to SNAREs

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