Diego Varela, Gerald W. Zamponi Neuron

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Presentation transcript:

Use ‘em and Lose ‘em—Activity-Induced Removal of Calcium Channels from the Plasma Membrane Diego Varela, Gerald W. Zamponi Neuron Volume 55, Issue 4, Pages 539-541 (August 2007) DOI: 10.1016/j.neuron.2007.07.033 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Trafficking and Regulation of L-Type Calcium Channels (Left) The calcium channel α1 subunit is coassembled with β and α2-δ subunits in the ER and targeted to the plasma membrane where it associates with calmodulin (CaM). (Middle) Entry of calcium (yellow circles) via L-type channels in response to brief depolarization results in calcium binding to calmodulin, and feedback inhibition via calcium-dependent channel inactivation. Calcium-bound calmodulin can also signal to the nucleus to mediate gene activation. (Right) Prolonged calcium channel activity triggers reversible, calcium-dependent internalization into endosomes (E) due to calcium-dependent recruitment of eIF3e to the channel's II-III linker region. Possible transfer to a lysosomal compartment (Ly) may degrade the channel protein, leaving the L-type channel C terminus available for nuclear signaling. Neuron 2007 55, 539-541DOI: (10.1016/j.neuron.2007.07.033) Copyright © 2007 Elsevier Inc. Terms and Conditions