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CaV1.2 Calcium Channels: Just Cut Out to Be Regulated?

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Presentation on theme: "CaV1.2 Calcium Channels: Just Cut Out to Be Regulated?"— Presentation transcript:

1 CaV1.2 Calcium Channels: Just Cut Out to Be Regulated?
Rachel D. Groth, Natasha N. Tirko, Richard W. Tsien  Neuron  Volume 82, Issue 5, Pages (June 2014) DOI: /j.neuron Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 Midbody Proteolytic Cleavage of the Basic CaV1.2 Pore-Forming Unit This Ca2+-dependent cleavage, here illustrated for the II-III linker (left), gives rise to fragments that can remain together in a functional state (top right). The fragments can also dissociate and form a mosaic pattern in the surface membrane (bottom right), raising questions about their possible functional significance. Neuron  , DOI: ( /j.neuron ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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