Principal component analysis of adipose tissue fatty acids.

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Principal component analysis of adipose tissue fatty acids. Principal component analysis of adipose tissue fatty acids. In the scatter plot of the second principal component against the first principal component (in which the X axis represents the first principal component and the Y axis represents the second principal component), the coordinates of each fatty acid equals the coefficients of correlation between the fatty acid and the principal components. The unity correlation circle drawn defines the limits in which the fatty acids locate: the closer a fatty acid to this unity circle, the higher its contribution to the definition of the principal components. The ω6/ω3 ratio is located as illustrative variables—i.e., it does not contribute to the definition of the principal components, but it is positioned in the scatter plot according to its correlation with the two principal components. Red arrow, increased risk of breast cancer, taking into account the OR associated with both the X and Y axis, adjusted for BMI, age, menopausal status, and height. The position of this arrow is almost superposed on the Y axis because the OR associated with the first component is close to 1, whereas the OR associated with the second principal component is 1.28 (95% CI, 1.11-1.49; P = 0.001). Philippe Bougnoux et al. Cancer Epidemiol Biomarkers Prev 2006;15:416-421 ©2006 by American Association for Cancer Research