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Genomic DNA methylation (ng mCyt/μg DNA) according to combined MTHFR 1298A>C and 677C>T genotypes and low or high plasma folate levels (i.e., below or.

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Presentation on theme: "Genomic DNA methylation (ng mCyt/μg DNA) according to combined MTHFR 1298A>C and 677C>T genotypes and low or high plasma folate levels (i.e., below or."— Presentation transcript:

1 Genomic DNA methylation (ng mCyt/μg DNA) according to combined MTHFR 1298A>C and 677C>T genotypes and low or high plasma folate levels (i.e., below or above the median, 12 nmol/L). Genomic DNA methylation (ng mCyt/μg DNA) according to combined MTHFR 1298A>C and 677C>T genotypes and low or high plasma folate levels (i.e., below or above the median, 12 nmol/L). Statistical difference was evaluated by Student's t test. The reduced DNA methylation was evident only for 1298AA/677TT genotype carriers with low plasma folate, whereas among 1298AA/677TT subjects under adequate conditions of plasma folate, the levels of genomic DNA methylation were similar to that of the other two MTHFR genotype groups. The difference in DNA methylation between low- and high-folate subjects in the 1298AA/677TT group was statistically significant (2.44 versus 8.31 ng mCyt/μg DNA, P < ). Simonetta Friso et al. Cancer Epidemiol Biomarkers Prev 2005;14: ©2005 by American Association for Cancer Research

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