Fig. 1 Collecting popliteal lymphatic vessels exhibit diminished contraction and lymph velocity after MRSA infection. Collecting popliteal lymphatic vessels.

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Date of download: 6/27/2016 Copyright © 2016 SPIE. All rights reserved. Schematic showing the principle of calculating the TD between the contractile waves.

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Fig. 1 Collecting popliteal lymphatic vessels exhibit diminished contraction and lymph velocity after MRSA infection. Collecting popliteal lymphatic vessels exhibit diminished contraction and lymph velocity after MRSA infection. C57BL/6 mice were infected subcutaneously in the hindlimb with 2 × 106 to 4 × 106 colony-forming units (CFU) of MRSA for 4 days or left uninfected. (A) Representative sequential images from intravital microscopy of PLVs perfused with FITC-dextran (2 million molecular weight). Scale bar, 50 μm (see movies S1 and S2). (B) Representative traces from PLV wall measurements show lymphatic diameter and contraction over time (n = 8 to 11, each group). (C) Ejection fraction, indicating strength of lymphatic vessel contraction, in uninfected mice and mice infected with WT MRSA after 4 days (n = 8 to 11, each group). (D) Frequency indicates the counts per minute (cpm) of PLV contractions in uninfected mice and mice infected with WT MRSA after 4 days (n = 7 to 10, each group). (E) Top: Representative depth versus time image of the optical coherence tomography intensity signal (grayscale) from a fixed transverse location that is used to identify the upper and lower boundaries of PLVs in uninfected animals and during active infection (day 4). LV, lymphatic vessel. Instantaneous lymph velocity (color) in the PLV in uninfected animals and during active infection (day 4) is overlaid on structural OCT depth scan. Bottom: Representative trace of instantaneous velocity of lymph flow averaged over the PLV cross-sectional area in uninfected animals and during active infection (day 4). (F) Time-averaged mean velocity of lymph flow in uninfected animals and during active infection (n = 3 to 11 measurements in each group). For (C), (D), and (F), statistical analysis was performed using Student’s unpaired two-sided t test. Error bars show SEM. *P < 0.05. Dennis Jones et al., Sci Transl Med 2018;10:eaam7964 Published by AAAS