Role of Niacin in Current Clinical Practice: A Systematic Review

Slides:

Advertisements

Similar presentations

Low-Dose Aspirin in Patients with Stable Cardiovascular Disease: A Meta-analysis Jeffrey S. Berger, MD, MS, David L. Brown, MD, Richard C. Becker, MD The.

Advertisements

Prognostic Value of Morning Blood Pressure Surge in Clinical Events: A Meta-analysis of Longitudinal Studies Jun-Chao Xie, Han Yan, Yan-Xin Zhao, PhD,

Low-Dose Aspirin for Primary Prevention of Cardiovascular Events in Patients With Diabetes: A Meta-Analysis Stavros Stavrakis, MD The American Journal.

The Epidemic of the 20th Century: Coronary Heart Disease

Current Problems in Cardiology

Optimal Systolic Blood Pressure Target After SPRINT: Insights from a Network Meta- Analysis of Randomized Trials Sripal Bangalore, MD, MHA, Bora Toklu,

New-onset Atrial Fibrillation Predicts Heart Failure Progression

Amay Parikh, MD, MBA, MS, Kunal Gupta, MD, MBA, Alan C

The Effect of Smoking on the Risk of Sciatica: A Meta-analysis

Alfred A. Bartolucci, PhD, Michal Tendera, MD, George Howard, DrPH

The Diabetes Shared Care Program and Risks of Cardiovascular Events in Type 2 Diabetes Edy Kornelius, MD, Jeng-Yuan Chiou, PhD, Yi-Sun Yang, PhD, MD,

Shelley R. Salpeter, MD, FACP, Andrew J. Wall, MD, Nicholas S. Buckley

Alternative Smoking Cessation Aids: A Meta-analysis of Randomized Controlled Trials Mehdi Tahiri, MD, Salvatore Mottillo, MD, Lawrence Joseph, PhD, Louise.

Ahmed Abuzaid, MD, Carly Fabrizio, DO, Kevin Felpel, MD, Haitham S

An Unusual Cause of Leg Ulcerations

Duration of Dual Antiplatelet Therapy in Patients with an Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Chirag Bavishi, MD, MPH,

Impact of More Restrictive Blood Transfusion Strategies on Clinical Outcomes: A Meta- analysis and Systematic Review Shelley R. Salpeter, MD, Jacob S.

Alexander A. Leung, MD, MPH, Finlay A. McAlister, MD, MSc, Samuel R. G

Alternative Smoking Cessation Aids: A Meta-analysis of Randomized Controlled Trials Mehdi Tahiri, MD, Salvatore Mottillo, MD, Lawrence Joseph, PhD, Louise.

Recurrent infarction causes the most deaths following myocardial infarction with left ventricular dysfunction Stein Ørn, MD, John G.F. Cleland, MD, Matti.

Prevalence, Predictors, and Outcomes in Treatment-resistant Hypertension in Patients with Coronary Disease Sripal Bangalore, MD, MHA, Rana Fayyad, PhD,

Early Invasive Versus Initial Conservative Strategies for Women with Non–ST-Elevation Acute Coronary Syndromes: A Nationwide Analysis Islam Y. Elgendy,

Samy Suissa, PhD, Abbas Kezouh, PhD, Pierre Ernst, MD, MSc

Effect of beta-blockers on perioperative outcomes in vascular and endovascular surgery: a systematic review and meta-analysis S Hajibandeh, S Hajibandeh,

Introduction The American Journal of Medicine

Systematic Review and Meta-analysis of Adverse Events of Low-dose Aspirin and Clopidogrel in Randomized Controlled Trials Kenneth R. McQuaid, MD, Loren.

Todd A. Lee, PharmD, PhD, Brian Bartle, MPH, Kevin B. Weiss, MD, MPH

Net Clinical Benefit of Non-vitamin K Antagonist Oral Anticoagulants Versus Warfarin in Phase III Atrial Fibrillation Trials Giulia Renda, MD, PhD, Marta.

Effect of Aspirin on Mortality in the Primary Prevention of Cardiovascular Disease Nina Raju, MD, MsC, Magdalena Sobieraj-Teague, MBBS, Jack Hirsh, MD,

Body Mass Index and Mortality in Acute Myocardial Infarction Patients

Thyroid antibodies and gestational diabetes mellitus: a meta-analysis

The Epidemic of the 20th Century: Coronary Heart Disease

Robert Goulden, MBBS, MSc, MPhil, MA The American Journal of Medicine

Sabina Hunziker, MD, MPH, Jennifer Stevens, MD, MS, Michael D

Age and Gender Differences in Quality of Care and Outcomes for Patients with ST- segment Elevation Myocardial Infarction Sripal Bangalore, MD, MHA, Gregg.

Duration of Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation in Patients With and Without Acute Coronary Syndrome Abhishek Sharma, MD,

Muhammad Amer, MD, MHS, FACP, Rehan Qayyum, MD, MHS

The Reply The American Journal of Medicine

TIA for the Internist The American Journal of Medicine

Hong-Tao Tie, MD, Rui Shi, MD The American Journal of Medicine

Optimal Systolic Blood Pressure Target After SPRINT: Insights from a Network Meta- Analysis of Randomized Trials Sripal Bangalore, MD, MHA, Bora Toklu,

Gout in African Americans

Cardiovascular Risks of Exogenous Testosterone Use Among Men: A Systematic Review and Meta-Analysis G. Caleb Alexander, MD, MS, Geetha Iyer, MBBS, Eleanor.

Interaction of Physical Activity and Body Mass Index on Mortality in Coronary Heart Disease: Data from the Nord-Trøndelag Health Study Trine Moholdt,

Subclinical Hypothyroidism and the Risk of Coronary Heart Disease: A Meta-Analysis Nicolas Rodondi, MD, MAS, Drahomir Aujesky, MD, MS, Eric Vittinghoff,

The Safety and Efficacy of Mineralocorticoid Receptor Antagonists in Patients Who Require Dialysis: A Systematic Review and Meta-analysis Kevin Quach,

Impact of diabetes on carotid artery revascularization

Do the EXCEL and NOBLE Trial Results Change Meta-Analysis Findings?

Yin-Shu Chang, MD, Jia-Xiang Wang, MD, PhD, Da-Wei Chang, PhD

Eplerenone Is Not Superior to Older and Less Expensive Aldosterone Antagonists Saurav Chatterjee, MD, Chaim Moeller, MD, Nidhi Shah, MD, Oluwaseyi Bolorunduro,

Shelley R. Salpeter, MD, Peter Gregor, MD, Thomas M

Effect of diastolic dysfunction on postoperative outcomes after cardiovascular surgery: A systematic review and meta-analysis Roop Kaw, MD, Adrian V.

Does Methylphenidate Reduce the Symptoms of Chronic Fatigue Syndrome?

Clinical Outcomes After Treatment of Cocaine-Induced Chest Pain with Beta-Blockers: A Systematic Review and Meta-Analysis Kevin Bryan Lo, MD, Hafeez.

MATCH Results: Implications for the Internist

Shannon M. Dunlay, MD, MS, Quinn R. Pack, MD, Randal J

Prevalence and Risk Factors for Erectile Dysfunction in the US

To Reduce Stroke with PFO Closure, Respect the Shunt

Ahmed Abuzaid, MD, Carly Fabrizio, DO, Kevin Felpel, MD, Haitham S

Long-term Effect of Chronic Oral Anticoagulation with Warfarin after Acute Myocardial Infarction Salman A. Haq, MD, John F. Heitner, MD, Terrence J.

One-way Versus Two-way Text Messaging on Improving Medication Adherence: Meta- analysis of Randomized Trials David S. Wald, MD, FRCP, Shahena Butt, MSc,

Strategies for Optimizing Glycemic Control and Cardiovascular Prognosis in Patients With Type 2 Diabetes Mellitus James H. O'Keefe, MD, Mohammad Abuannadi,

Combining Antiplatelet and Antithrombotic Therapy (Triple Therapy): What Are the Risks and Benefits? Luis Alejandro Asencio, MD, Jennifer J. Huang, DO,

Diabetes, prediabetes, and cardiovascular risk: Shifting the paradigm

Nicholas Z. Kerin, MD, Sony Jacob, MD The American Journal of Medicine

The Journal of Thoracic and Cardiovascular Surgery

Higher Cardiovascular Disease Prevalence and Mortality among Younger Blacks Compared to Whites Stacey Jolly, MD, MS, Eric Vittinghoff, PhD, Arpita Chattopadhyay,

Falls in Older Adults: Risk Assessment, Management and Prevention

Longer Lengths of Stay and Higher Risk of Mortality among Inpatients of Physicians with More Years in Practice William N. Southern, MD, MS, Eran Y. Bellin,

Preoperative Thienopyridine Use and Outcomes after Surgery: A Systematic Review Anita G. Au, MD, Sumit R. Majumdar, MD MPH, Finlay A. McAlister, MD MSc

Presentation transcript:

Role of Niacin in Current Clinical Practice: A Systematic Review Aakash Garg, MD, Abhishek Sharma, MD, Parasuram Krishnamoorthy, MD, Jalaj Garg, MD, Deepti Virmani, MD, Toishi Sharma, MD, Giulio Stefanini, MD, John B. Kostis, MD, Debabrata Mukherjee, MD, MS, Ekaterina Sikorskaya, MD The American Journal of Medicine Volume 130, Issue 2, Pages 173-187 (February 2017) DOI: 10.1016/j.amjmed.2016.07.038 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 The PRISMA flow chart for the trial selection process. The American Journal of Medicine 2017 130, 173-187DOI: (10.1016/j.amjmed.2016.07.038) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 2 Forest plot showing effect of niacin on risk of all-cause mortality. CI = confidence interval; RR = risk ratio. For full trial names, see Table 1 footnote. The American Journal of Medicine 2017 130, 173-187DOI: (10.1016/j.amjmed.2016.07.038) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 3 Forest plot showing effect of niacin on risk of cardiovascular (CV) mortality. CI = confidence interval; RR = risk ratio. For full trial names, see Table 1 footnote. The American Journal of Medicine 2017 130, 173-187DOI: (10.1016/j.amjmed.2016.07.038) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 4 Forest plot showing effect of niacin on coronary death. CI = confidence interval; RR = risk ratio. For full trial names, see Table 1 footnote. The American Journal of Medicine 2017 130, 173-187DOI: (10.1016/j.amjmed.2016.07.038) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 5 Forest plot showing effect of niacin on myocardial infarction (MI). CI = confidence interval; RR = risk ratio. For full trial names, see Table 1 footnote. The American Journal of Medicine 2017 130, 173-187DOI: (10.1016/j.amjmed.2016.07.038) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 6 Forest plot showing effect of niacin on revascularization rates. CI = confidence interval; RR = risk ratio. For full trial names, see Table 1 footnote. The American Journal of Medicine 2017 130, 173-187DOI: (10.1016/j.amjmed.2016.07.038) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 7 Forest plot showing effect of niacin on stroke. CI = confidence interval; RR = risk ratio. For full trial names, see Table 1 footnote. The American Journal of Medicine 2017 130, 173-187DOI: (10.1016/j.amjmed.2016.07.038) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 8 Forest plot showing effect of niacin on new-onset or worse control of pre-existing diabetes mellitus (DM). CI = confidence interval; M-H = Mantel-Haenszel. For full trial names, see Table 1 footnote. The American Journal of Medicine 2017 130, 173-187DOI: (10.1016/j.amjmed.2016.07.038) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 9 Forest plot showing effect of niacin on gastrointestinal (GI) adverse events. CI = confidence interval; M-H = Mantel-Haenszel. For full trial names, see Table 1 footnote. The American Journal of Medicine 2017 130, 173-187DOI: (10.1016/j.amjmed.2016.07.038) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 10 Forest plot showing effect of niacin on musculoskeletal adverse events. CI = confidence interval; M-H = Mantel-Haenszel. For full trial names, see Table 1 footnote. The American Journal of Medicine 2017 130, 173-187DOI: (10.1016/j.amjmed.2016.07.038) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 11 Forest plot showing effect of niacin on skin flushing. CI = confidence interval; M-H = Mantel-Haenszel. For full trial names, see Table 1 footnote. The American Journal of Medicine 2017 130, 173-187DOI: (10.1016/j.amjmed.2016.07.038) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 12 Forest plot showing effect of niacin on liver toxicity. CI = confidence interval; M-H = Mantel-Haenszel. For full trial names, see Table 1 footnote. The American Journal of Medicine 2017 130, 173-187DOI: (10.1016/j.amjmed.2016.07.038) Copyright © 2016 Elsevier Inc. Terms and Conditions