Interleukin signaling

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Presentation transcript:

Interleukin signaling Christian A.J Voßhenrich, James P Di Santo Current Biology Volume 12, Issue 22, Pages R760-R763 (November 2002) DOI: 10.1016/S0960-9822(02)01286-1

Figure 1 Signal transduction via type I and type II cytokine receptors. (A) Ligand-induced oligomerisation of receptor subunits leads to receptor phosphorylation thereby recruiting Shc and STAT proteins. (B) Pathways of Shc-mediated PKB and MAPK activation and STAT-induced SOCS/CIS/PIAS inhibition. See text for details. Current Biology 2002 12, R760-R763DOI: (10.1016/S0960-9822(02)01286-1)

Figure 2 Signal transduction via the IL-1 receptor. (A) Building of the signaling-proficient receptor-ligand complex consisting of IL-1, IL-1R1 and IL-1RAcP allows for the recruitment of MyD88 via the TIRdomain. (B) Recruitment of the TOLLIP-IRAK-IRAK4 complex to the receptor. (C) Autophosphorylation and subsequent dissociation of IRAK-IRAK4. (D) Binding of TRAF6 by IRAK-IRAK4. (E) TRAF6-mediated activation of NF-κB and MAPK, probably via TAK1 and MKK6, respectively. See text for details. Current Biology 2002 12, R760-R763DOI: (10.1016/S0960-9822(02)01286-1)