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cIAP Proteins: Keystones in NOD Receptor Signal Transduction

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Presentation on theme: "cIAP Proteins: Keystones in NOD Receptor Signal Transduction"— Presentation transcript:

1 cIAP Proteins: Keystones in NOD Receptor Signal Transduction
Colin Reardon, Tak W. Mak  Immunity  Volume 30, Issue 6, Pages (June 2009) DOI: /j.immuni Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Figure 1 cIAPs Orchestrate NOD-Induced Signaling
Detection of bacterially derived DAP by NOD1 and MDP by NOD2 result in cIAP1 and 2 binding to RIP2. Both cIAP1 and cIAP2 function as E3 ligases of RIP2, resulting in the conjugation of K63 polyubiquitin chains to RIP2. These events precede binding and activation of TAK1, which is required to initiate NF-kB and MAPK signaling. Immunity  , DOI: ( /j.immuni ) Copyright © 2009 Elsevier Inc. Terms and Conditions

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