Figure 1. Survival curves from a hypothesized clinical trial randomizing patient to standard of care with and without ... Figure 1. Survival curves from.

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Presentation transcript:

Figure 1. Survival curves from a hypothesized clinical trial randomizing patient to standard of care with and without ... Figure 1. Survival curves from a hypothesized clinical trial randomizing patient to standard of care with and without an experimental therapy and a biomarker is present in 50% of the population under three scenarios: (A) a purely predictive biomarker; (B) a purely prognostic biomarker; and (C) a predictive and prognostic biomarker. For each scenario, the top row shows the overall population, and the two bottom rows show the biomarker-positive and biomarker-negative subgroups, respectively. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Ann Oncol, mdz087, https://doi.org/10.1093/annonc/mdz087 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 2. Survival curves of the overall trial population from a hypothesized clinical trial with a predictive and ... Figure 2. Survival curves of the overall trial population from a hypothesized clinical trial with a predictive and prognostic biomarker with varying (A–C) biomarker prevalence, (D–F) biomarker prognostic effect, and (G) biomarker predictive effect. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Ann Oncol, mdz087, https://doi.org/10.1093/annonc/mdz087 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 3. Kaplan–Meier estimates for overall survival derived from reconstructed data from RTOG 9402 [19], evaluating ... Figure 3. Kaplan–Meier estimates for overall survival derived from reconstructed data from RTOG 9402 [19], evaluating the addition of procarbazine, lomustine, and vincristine (PCV) chemotherapy to radiation therapy (RT) in patients with anaplastic oligodendroglioma and anaplastic oligoastrocystoma in the (A) overall population with (B) estimates of the hazard ratio over time with a 95% confidence interval. Kaplan–Meier estimates are also presented for patients (C) with 1p/19q co-deletion and (D) without the 1p/19q co-deletion. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Ann Oncol, mdz087, https://doi.org/10.1093/annonc/mdz087 The content of this slide may be subject to copyright: please see the slide notes for details.