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S ystolic H eart failure treatment with the I f inhibitor ivabradine T rial Selective heart rate reduction with ivabradine unloads the left ventricle in.

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Date of download: 9/16/2016 Copyright © The American College of Cardiology. All rights reserved. From: Oxygen-Saving Effect of a New Cardiotonic Agent,

Figure 1 Initial management of a patient with acute heart failure

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Figure 1 Mechanisms of action of novel therapeutics for heart failure

Figure 2 Different manifestations of myocardial ischaemia

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Figure 8 Implanted devices for the management of heart failure

Figure 4 BMI and mortality in patients with heart failure

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Figure 1 Energy supply–demand matching in health and heart failure

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Figure 3 Ischaemic outcomes in the ST-segment elevation myocardial

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Figure 8 4D magnetic resonance imaging patterns

Figure 4 Effects of delaying cardioprotective medications after anthracycline administration Figure 4 | Effects of delaying cardioprotective medications.

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Figure 4 Prevalence of HFpEF and HFrEF by age

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Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Cardiol. doi: /nrcardio

Figure 1 Decision tree integrating the assessment,

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Figure 3 Neural crest cell migration

Figure 2 Global cost of HF per capita in 2012

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Figure 2 A patient with aortic stenosis and mitral regurgitation

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Heart Failure. Enhancing Myosin Activation and Cardiac Contractility: Implications for Heart Failure.

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Figure 2 Absolute difference in seasonal peak

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Figure 6 The neurogenic components of angina

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Figure 1 Ventricular end-diastolic pressure–volume relationship curves

Figure 6 The haemodynamic effects of

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Figure 4 Electrocardiogram patterns associated with Brugada syndrome

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Figure 2 Impaired mitochondrial capacity and function in heart failure

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Figure 3 Matrix signals regulate valve cell phenotypes

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Figure 3 Adverse cardiovascular consequences of synthetic cannabinoids

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Presentation transcript:

Nat. Rev. Cardiol. doi:10.1038/nrcardio.2015.137 Figure 2 Effects of conventional versus novel inotropes on cardiac contractility in vivo Figure 2 | Effects of conventional versus novel inotropes on cardiac contractility in vivo. The effects of dobutamine and omecamtiv mercabil on time-dependent elastance were compared in dogs with heart failure induced by chronic rapid cardiac pacing together with localized myocardial infarction. TE[max] and TE[min] at baseline are shown, along with the changes induced on treatment. Whereas the conventional inotrope dobutamine increased stroke volume from baseline via increases in the rate of left ventricular pressure increase, omecamtiv mecarbil prolonged ejection time in the absence of alterations in this rate. Abbreviations: TE[max], time to maximum elastance; TE[min], time to minimum elastance. Permission obtained from the American Association for the Advancement of Science © Malik, F. I. et al. Cardiac myosin activation: a potential therapeutic approach for systolic heart failure. Science 331, 1439–1443 (2011). Permission obtained from the American Association for the Advancement of Science © Malik, F. I. et al. Cardiac myosin activation: a potential therapeutic approach for systolic heart failure. Science 331, 1439–1443 (2011) von Lueder, T. G. & Krum, H. (2015) New medical therapies for heart failure Nat. Rev. Cardiol. doi:10.1038/nrcardio.2015.137