Longevity of mucosal and systemic antibody responses induced by pulmonary vaccination. Longevity of mucosal and systemic antibody responses induced by.

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Volume 22, Issue 7, Pages (July 2014)

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Detection of CSFV-specific antibodies in immunized/challenged pigs using blocking ELISA. Groups of pigs (n = 5) were inoculated with different doses of.

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Comparison of relative activity of Adjuplex and other commonly used adjuvants. Comparison of relative activity of Adjuplex and other commonly used adjuvants.

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Mean reciprocal IFA titer results for serum samples from experimentally vaccinated animals. Mean reciprocal IFA titer results for serum samples from experimentally.

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Presentation transcript:

Longevity of mucosal and systemic antibody responses induced by pulmonary vaccination. Longevity of mucosal and systemic antibody responses induced by pulmonary vaccination. Sheep received three vaccinations of 15 μg of influenza antigen and 75 Isco units of Iscomatrix adjuvant, delivered into the deep lung. Negative-control unvaccinated sheep (n = 12) received PBS alone. Serum and lung washings, collected 1 (n = 12), 3 (n = 12), 6 (n = 12), and 12 (n = 6) months after the third vaccination, were analyzed for the presence of anti-influenza virus IgG and IgA antibodies by ELISA. Immunization via the pulmonary route induced a significant antibody response for up to 6 months postvaccination compared with that of unvaccinated controls (*, P < 0.035; ANOVA). Ana Vujanic et al. Clin. Vaccine Immunol. 2012; doi:10.1128/CVI.05265-11