Activated membrane signaling promotes survival in response to radiation. Activated membrane signaling promotes survival in response to radiation. Radiation.

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Presentation transcript:

Activated membrane signaling promotes survival in response to radiation. Activated membrane signaling promotes survival in response to radiation. Radiation activates a series of cellular signaling pathways that promote repair of radiation-induced DNA damage as well as other cellular processes (green boxes). Many of these radiation-induced prosurvival pathways can be targeted with small-molecule inhibitors or antibodies. Inhibition of these radiation-induced, prosurvival pathways potentially results in maximal potentiation of chemoradiation. EMT, epithelial-to-mesenchymal transition. Meredith A. Morgan et al. Cancer Discovery 2014;4:280-291 ©2014 by American Association for Cancer Research