Transplanted NPCs survive, migrate, differentiate morphologically, and integrate within the corpus callosum. Transplanted NPCs survive, migrate, differentiate.

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Transplanted NPCs survive, migrate, differentiate morphologically, and integrate within the corpus callosum. Transplanted NPCs survive, migrate, differentiate morphologically, and integrate within the corpus callosum. At P21, injury is visible by MRI and includes the thinning of the CC (outlined in yellow) and a right ventriculomegaly. A, NPCs were transplanted in the right/ipsilateral/injured CC at PND21. B–I, The NPCs migrated and spread through the CC. Their morphology changed from a round-type (in vitro) to a fibroblast-like cell type and, subsequently, to a cell with multiple processes. I, Transplanted NPCs (green) are counterstained by DAPI (blue; b1–b3). The NPCs survived >19 weeks after transplantation. J, The survival rate was similar in the HI and sham animal after 9 weeks. Prakasham Rumajogee et al. eNeuro 2018;5:ENEURO.0369-18.2018 ©2018 by Society for Neuroscience