1. IANX transiently increased cortical responses to maxillary molar pulp stimulation.
IANX transiently increased cortical responses to maxillary molar pulp stimulation. A, Examples of cortical responses evoked by electrical stimulation of the maxillary molar pulp in the sham (1w-sham and 4w-sham) and IANX model (1w-IANX, 2w-IANX, and 4w-IANX) groups. The time from the onset of the electrical stimulation is shown at the top of each panel. B, Temporal profiles of optical signals in ROIs (white circles) in S2/IOR shown in A. C, Comparison of the peak amplitude, latency, and time to peak of optical signals responding to the stimulation. The numbers of animals are shown in parenthesis. Note that there was no significant difference between the 1w-sham and 4w-sham groups (Student’s t test or Mann–Whitney U test). D, Superimposed images of the maximum responses evoked by the maxillary molar pulp stimulation. The number of overlapping responses is represented by the gradation of the colors. The line outlines the area responding to stimulation in 50% of animals. E, Comparison of areas activated by the stimulation. Note the significant increases in the excitation area in the 1w-IANX and 2w-IANX groups (Mann–Whitney U test). F, Comparison of the excitation area shown in D. Solid and dashed lines indicate the responding area in 50% of the animals in the IANX model and sham groups, respectively. Note that the activated area expanded primarily dorsally in the 1w-IANX and 2w-IANX groups; *p ≤ 0.017, **p < 0.01, Mann–Whitney U test.
Satoshi Fujita et al. eNeuro 2019;6:ENEURO
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