ROC curve for separating advanced stages (advanced BE and EA) versus early stages (BE or BE instability) using total genome-wide LOH [area under the curve.

Slides:



Advertisements
Similar presentations
PIK3CA gene amplification in glioblastoma and squamous cell carcinoma (SCC) of the lung. PIK3CA gene amplification in glioblastoma and squamous cell carcinoma.
Advertisements

Zhi-hui Hou et al. JIMG 2012;5:
Genomic DNA methylation (ng mCyt/μg DNA) according to combined MTHFR 1298A>C and 677C>T genotypes and low or high plasma folate levels (i.e., below or.
Discriminatory performance (receiver operating characteristics (ROC) analysis) of lung clearance index (LCI) analysed with the different methods. a) ROC.
Distribution of informative SNPs with LOH (black bars) on each chromosome (rows, oriented p-arm at the bottom and q-arm at the top of each chromosome)
Number of 0.5-Mb windows with chromosome lesions that reached statistical significance across patients in early (BE early and BE instability) and late.
Chromosome 8 cDNA microarray gene expression profile of the amplified regions of 8p11–12 in SUM-44, -52, and -225 cells versus MCF10A HME control cells.
A, genomic copy number profiles of chromosome 8 with array CGH in SUM-44, -52, and A, genomic copy number profiles of chromosome 8 with array CGH.
Normal cells (orange), often after long-term exposure to carcinogens, can obtain changes in key molecular pathways and cause uncontrolled proliferation.
Christopher T. Nguyen et al. BTS 2018;3:97-109
Comparative receiver operating characteristic (ROC) curves and the area under the curve (AUC) in association with 30-day mortality for severity scores.
Receiver operating characteristic curves (ROC) for the metabolites between the systemic inflammatory response syndrome (n=15) and sepsis (n=35) groups.
Schematic representation of experimental design for BSp dietary treatments. Schematic representation of experimental design for BSp dietary treatments.
Receiver operating characteristic (ROC) curves (area under the curve (AUC) (95% CI)) for FACED (forced expiratory volume in 1 s, age, chronic colonisation.
—ROC curves for each simple test compared with NCS (gold standard) plotting the sensitivity versus 1-specificity (the false-positive rate) for different.
Fig. 3 ROC curves of mCCNA1 and mVIM assayed in esophageal cytology brushings from control normal-appearing GE junctions versus BE and EAC cases. ROC curves.
A, IC50 dose–response curves of SYD985, T-DM1, and ADC isotype control in all USC cell lines tested in vitro (i.e., HER2 3+ cell lines, P =
Changes in the ratio of (EPA+DHA):AA in the breast triacylglyceride compartment. Changes in the ratio of (EPA+DHA):AA in the breast triacylglyceride compartment.
Receiver-operating characteristic curves showing the performance of the diabetes risk score in predicting diabetes in the United Arab Emirates (UAE) citizens.
The figure shows the mean±SD of glucose and insulin for the 2-hour OGTTs and MTTs for the 12 HP diet subjects and the 12 HC diets subjects. The figure.
Quantitation of PCR products.
BRCA1 promoter methylation detected in the peripheral blood and corresponding tumor. BRCA1 promoter methylation detected in the peripheral blood and corresponding.
Effects of AG on the colon histology score in the acute DSS colitis model. Effects of AG on the colon histology score in the acute DSS colitis model. Ten.
Schematic of experimental parameters comparing FFPE DNA repair methods to FF DNA. DNA (500 ng) from FF tissue was processed according to Illumina Human.
Diagnostic performance of dentist clinical impression.
Association between RB pathway alterations and poor prognosis in early-stage lung adenocarcinoma patients. Association between RB pathway alterations and.
Effects of maternal exposure during pregnancy to tap water (control), LIM, or HIM on offspring tumor incidence (% rats with tumors; A), tumor multiplicity.
Heat map of genes for which CR significantly altered expression versus AL. Cluster analysis of genes significantly changed by the CR intervention compared.
A, scatterplots of qMSP analysis of candidate genes promoters in the prevalence screen cohort, which consisted of 55 HNSCC tumor tissue samples and 37.
Correlation between serum visfatin concentrations and the clinical stage (A) and tumor size (B, C) of HCCs. A and B, the correlations were determined by.
A, one-step viral growth curves: RT treatment increased the virus yield in MV-CEA–treated U87 cells by up to 2 log as compared with MV-CEA infection only.
The effect of IAA and glycyrrhizin (Gc) on growth of human melanoma cells. The effect of IAA and glycyrrhizin (Gc) on growth of human melanoma cells. A,
Overview of TIMER modules on the website.
PKM2 activation was suppressed by overexpression of MnSOD during early skin carcinogenesis. PKM2 activation was suppressed by overexpression of MnSOD during.
A, Proportion of variants detected in the MMR genes.
Gene copy number analysis by multiplexed quantitative differential PCR for BRCA1 and BRCA2 for 23 DNA specimens obtained from patients of Hispanic ancestry.
Validation of GHSR, SST, and ZIC1 in hrHPV-positive cervical scrapes and their relation to duration of lesion existence and DNA copy number aberrations.
Receiver operating characteristic (ROC) curves assessing pre-trilostane, three-hour post-trilostane and post-adrenocorticotrophic hormone (ACTH) cortisol.
Growth curve (a) and doubling time (b) of glioma cells.
Analysis of mRNA and protein levels of Loricrin, COMP, CXCL9, KRT19, and CYP 3A5 genes in OSFs compared with normal controls. Analysis of mRNA and protein.
Cumulative urinary excretion of aflatoxin equivalents in subjects 1, 2, and 5. Cumulative urinary excretion of aflatoxin equivalents in subjects 1, 2,
MPM cases with GNH. A, WES-based LOH profiling with the FACETS algorithm revealed three MPM samples with genome-wide LOH. B, Allelic copy-number plots.
WP1066 inhibits the progression of OCIM2 cells through the cell cycle.
The percentage of positive among all women (A), women with CIN2, or more severe diagnosis (CIN2+; sensitivity; B), and grade 3 (CIN3) or more severe diagnosis.
Correlations of the breast cancer hypoxia metagene with Ki67 and the proliferation metagene. Correlations of the breast cancer hypoxia metagene with Ki67.
Representative images demonstrating LOH in breast cancer patients’ paired BM aspirate and primary tumors (T) at D14S62, D14S51, and D8S321, respectively.
High-risk neuroblastoma molecular subtypes classification and inference of master regulators. High-risk neuroblastoma molecular subtypes classification.
Influence of ASGR2 expression on survival.
Association of MTR A2756G with risk of localized and advanced prostate cancer: dominant model comparing (G/G and A/G) versus A/A genotypes (I-V, inverse-variance.
Effects of maternal exposure to tap water (control), LIM, or HIM from GD 11 until birth on VO among female offspring (n = 28, 47, and 36 in the control,
Kaplan–Meier curves for RFS and OS by various marker groups.
The influence of diverse genotypes of rs on the expression of TRAF3 (A), IFNβ (B), in PBMCs of healthy individuals. The influence of diverse genotypes.
Selected overview of clinical trials evaluating FGFR signaling–targeted therapies currently under development (monotherapy). Selected overview of clinical.
Association of overall survival and PAP-specific (A, B) and PA2024-specific (C, D) CTL activity at week 26 using categorical (tertile) analysis and continuous.
Fig. 1 Number of somatic mutations in representative human cancers, detected by genome-wide sequencing studies. Number of somatic mutations in representative.
ROC analysis of MIC-1 and CA19-9.
Progastrin staining in colon adenomas and adenocarcinomas.
The influence of diverse genotypes of rs on the expression of MAVS (A), IFNβ (B), in PBMCs of healthy individuals. The influence of diverse genotypes.
A, LOH on chromosome 17q (D17S785; expected size, 181–207 bp) in SC-IDC (Lane 2), SC-DCIS (Lane 3), clear-cut normal epithelial cells (Lane 4), DCIS (Lane.
A, Proportion for different in silico predictions at the RNA level.
Patient stratification using survival risk prediction and BCLC staging
Recruitment of CD8+, CD4+, and Foxp3+ cells into oral lesions in response to anti–PD-1 treatment. Recruitment of CD8+, CD4+, and Foxp3+ cells into oral.
Receiver operating characteristic (ROC) curves for discriminating diabetic subjects without retinopathy from control subjects using a logistic regression.
Loss of NQO1 expression inhibits invasion of NSCLC
Epithelial and stromal percentage clusterin staining in normal nonadjacent colonic tissue and matched tumor tissue in 202 patients with stage II colorectal.
E2F4 program is predictive of the efficacy of intravesical BCG immunotherapy in NMIBC. A, the survival curves of intravesical therapy-treated and untreated.
Receiver operator characteristic (ROC) curve for fasting blood glucose (FBG) predicting posttransplantation diabetes (PTD) using time 0 FBG (a) and screening.
CONSORT diagram. a, 5 had a major treatment violation (3 refused and 2 received wrong treatment) but were included in the analyses; b, 4 had a major treatment.
Tumor growth in female progeny with prenatal/maternal, postnatal early-life, and postnatal adult BSp dietary administrations. Tumor growth in female progeny.
GSN and DNMT1 expression are inversely correlated in a pattern associated with patient survival. GSN and DNMT1 expression are inversely correlated in a.
Presentation transcript:

ROC curve for separating advanced stages (advanced BE and EA) versus early stages (BE or BE instability) using total genome-wide LOH [area under the curve (AUC) = 0.91] or copy gain and loss (area under the curve = 0.91). ROC curve for separating advanced stages (advanced BE and EA) versus early stages (BE or BE instability) using total genome-wide LOH [area under the curve (AUC) = 0.91] or copy gain and loss (area under the curve = 0.91). Xiaohong Li et al. Cancer Prev Res 2008;1:413-423 ©2008 by American Association for Cancer Research