Figure 2 A model of TNFR–complex I signalling

Slides:

Advertisements

Similar presentations

Tyrosine kinase signalling (review) TGF signalling Notch signalling.

Advertisements

TNF superfamily TNF: produced by macrophages, monocytes, lymphocytes, fibroblasts upon inflammation, infection, injury, environmental challenges.

Linear ubiquitination: A novel NF-κB regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex 陈洁

Receptor-Ligand Interactions.. k 1 R + L  RL K -1 [RL] Ka = _____ [R] [L] Affinity constant (M -1 ) [R] [L] Kd = ______ [RL] Dissociation constant.

Date of download: 6/21/2016 Copyright © 2016 McGraw-Hill Education. All rights reserved. Cellular signaling pathways for production ofinflammatory cytokines.

Date of download: 7/8/2016 Copyright © 2016 McGraw-Hill Education. All rights reserved. Cellular signaling pathways for production of inflammatory cytokines.

Cellular signaling pathways for production of inflammatory cytokines in response to microbial products. Microbial cell-surface constituents interact with.

Figure 1 Simplified scheme of TGFβ signalling

Figure 2 Inflammatory pathways affecting hepatic insulin resistance

Cellular and Molecular Mechanisms of Liver Injury

Figure 2 Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis Figure 2 | Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis.

Smac Mimetics and TNFα: A Dangerous Liaison?

Figure 4 Simplified T cell and antigen presenting

D.H. Dockrell Clinical Microbiology and Infection

Cellular and Molecular Mechanisms of Liver Injury

Figure 5 Defects in the JAK–STAT signalling pathway

Innate signals in mucosal immunoglobulin class switching

Nat. Rev. Endocrinol. doi: /nrendo

Toll-like receptors: Applications to dermatologic disease

NOD-like and Toll-like receptors or inflammasomes contribute to kidney disease in a canonical and a non-canonical manner Hans-Joachim Anders, Maciej.

Fas NF-κB JNK Bcl-2 Akt p21 Bax Ras TRAILR p53 EGFR TRADD Myc TNFR

Figure 7 Defects in apoptosis

Toll-like receptors in Borrelia burgdorferi-induced inflammation

Figure 3 Molecular mechanisms of crystal-induced necroinflammation

Whipping NF-κB to Submission via GADD45 and MKK7

Tumor necrosis factor: Biology and therapeutic inhibitors

Figure 2 Oestrogen receptor signalling pathways

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum

Keratins and the Keratinocyte Activation Cycle

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Transcriptional inflammatory response to hypoxia and cellular necrosis

Pathogen Recognition and Innate Immunity

The Two Faces of Receptor Interacting Protein Kinase-1

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches Ekihiro Seki, David A. Brenner, Michael.

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum

Immune defects caused by mutations in the ubiquitin system

Connecting Mitochondria and Innate Immunity

Cell Communication (Signaling) Part 3

Mitochondrial Signaling

Experimental Hematology

Signal transduction by TNF-α leads to apoptosis or necroptosis.

Death receptor-mediated apoptosis and the liver

Roles of Caspases in Necrotic Cell Death

The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation

Nat. Rev. Rheumatol. doi: /nrrheum

Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members Sophie Janssens, Rudi Beyaert Molecular.

Toll-like receptors Current Biology

Intracellular Toll-like Receptors

Manfred Fliegauf, PhD, Bodo Grimbacher, MD

Volume 19, Issue 5, Pages (September 2005)

NF-κB activation in pathogenesis and therapy of cancer.

Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart

Antigen-Receptor Signaling to Nuclear Factor κB

Cell Communication (Signaling) Part 3

RelA Life and Death Decisions

A possible mechanism of renal cell death after ischemia/reperfusion

Alterations to TNFR1 signaling and complex formation in the absence of TRADD. (A–C) ERK, JNK, and IκB. traddWT/WT and traddKO/KO MEFs (A) and BM-Macs (B)

Immunoregulatory role of TNFα in inflammatory kidney diseases

Components and outcomes of selected TNF-superfamily signalling pathways. Components and outcomes of selected TNF-superfamily signalling pathways. (Left)

The TNF Receptor 1 Cell Volume 114, Issue 2, Pages (July 2003)

Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members Sophie Janssens, Rudi Beyaert Molecular.

Sam68 Guest STARs in TNF-α Signaling

Macrophages, Immunity, and Metabolic Disease

Tumor necrosis factor: Biology and therapeutic inhibitors

NF-κB, Inflammation, and Metabolic Disease

Different signaling pathways of TLR2, Nod, and TNFR1 in response to ligand, resulting in activation of NF-κB, the nuclear transcriptional factor responsible.

Toll-like receptors, adapter proteins, and signaling molecules.

Presentation transcript:

Figure 2 A model of TNFR–complex I signalling Figure 2 | A model of TNFR–complex I signalling. The binding of homotrimeric TNF to homotrimeric TNF receptors (TNFRs) induces the formation of complex I, comprising TNFR1-associated death domain protein (TRADD), receptor-interacting serine/threonine-protein kinase 1 (RIPK1), TNFR-associated factor 2 (TRAF2), cellular inhibitor of apoptosis protein 1 (cIAP1) or cIAP2, and linear ubiquitin chain assembly complex (LUBAC). cIAPs and LUBAC decorate RIPK1 with scaffolding Lys63-linked and Met1-linked polyubiquitin chains, inducing the recruitment of transforming growth factor (TGF)-β-activated kinase 1 (TAK1) and inhibitor of κB (IκB) kinase (IKK) complexes. TAK1 activates p38 and JUN N-terminal kinase (JNK), leading to the transcription of AP1-target genes. IKKβ phosphorylates IκB, inducing its proteasomal degradation and the release of nuclear factor κB (NFκB). Free NFκB translocates to the nucleus, where it induces the expression of target genes. NEMO, NFκB essential modulator; TAB, TAK1-binding protein. Kalliolias, G. D. & Ivashkiv, L. B. (2015) TNF biology, pathogenic mechanisms and emerging therapeutic strategies Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2015.169