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Volume 16, Issue 15, Pages 1515-1524 (November 2015) Cediranib combined with carboplatin and paclitaxel in patients with metastatic or recurrent cervical cancer (CIRCCa): a randomised, double-blind, placebo-controlled phase 2 trial Prof R Paul Symonds, FRCR, Prof Charlie Gourley, PhD, Susan Davidson, MD, Karen Carty, Elaine McCartney, BSc, Debbie Rai, PhD, Susana Banerjee, PhD, David Jackson, PhD, Rosemary Lord, MBChB, Mary McCormack, FRCR, Emma Hudson, MBBCh, Prof Nicholas Reed, MBBS, Maxine Flubacher, MBBCh, Petra Jankowska, FRCR, Melanie Powell, MD, Prof Caroline Dive, PhD, Prof Catharine M L West, PhD, James Paul, BSc The Lancet Oncology Volume 16, Issue 15, Pages 1515-1524 (November 2015) DOI: 10.1016/S1470-2045(15)00220-X Copyright © 2015 Symonds et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 1 Trial profile *One patient in this group was given chemotherapy but did not receive any trial drug. †Two patients withdrew from the study before starting treatment and are censored for progression-free and overall survival at this point. The Lancet Oncology 2015 16, 1515-1524DOI: (10.1016/S1470-2045(15)00220-X) Copyright © 2015 Symonds et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 2 Progression-free survival The Lancet Oncology 2015 16, 1515-1524DOI: (10.1016/S1470-2045(15)00220-X) Copyright © 2015 Symonds et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 3 Overall survival The Lancet Oncology 2015 16, 1515-1524DOI: (10.1016/S1470-2045(15)00220-X) Copyright © 2015 Symonds et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 4 European Organisation for Research and Treatment of Cancer QLQ-C30 global health status by timepoint The circle is an outlier datapoint. The Lancet Oncology 2015 16, 1515-1524DOI: (10.1016/S1470-2045(15)00220-X) Copyright © 2015 Symonds et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 5 Mean sVEGFR2 concentration (log 10) by timepoint Error bars are standard errors. sVEGFR2=plasma-soluble VEGFR2. *Two baseline measurements were taken for each patient (these are replicate results). The Lancet Oncology 2015 16, 1515-1524DOI: (10.1016/S1470-2045(15)00220-X) Copyright © 2015 Symonds et al. Open Access article distributed under the terms of CC BY Terms and Conditions