The psoriatic phenotype of DKO

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The psoriatic phenotype of DKO The psoriatic phenotype of DKO* mice is exacerbated when Lan+ APCs are depleted during chronic disease APsoriatic disease was induced by five daily consecutive injections of Tx (▼), and Lan+ APCs were depleted by injection of DT (▲) at day 14 when psoriasis had developed (injections every third day). The psoriatic phenotype of DKO* mice is exacerbated when Lan+ APCs are depleted during chronic disease APsoriatic disease was induced by five daily consecutive injections of Tx (▼), and Lan+ APCs were depleted by injection of DT (▲) at day 14 when psoriasis had developed (injections every third day). Mice were euthanized on day 21. BMean psoriatic phenotype score of the indicated mice was determined on day 14 and day 21 after disease induction (n = 39–41). CRepresentative images of affected body parts of DKO* and DKO* LanDTR mice on day 14 and day 21 are shown. Arrows indicate sites of aggravated inflammation after Lan+ APC depletion. DRepresentative H&E staining of ear sections of indicated mice on day 21. Scale bars represent 500 μm (magnification 4×) and 200 μm (magnification 10×). E, FHistogram showing (E) epidermal and (F) dermal thickness of skin of mice of the indicated genotype. Ten randomly chosen fields of 3–4 independent images per mouse were analyzed (n = 9–19), magnification 4×. G, HQuantification of flow cytometric analysis showing (G) ear and tail epidermal immune cells (CD45+ cells), and (H) epidermal neutrophils/monocytes (CD45+Gr‐1+CD11b+ cells) of indicated mice (n = 8–12). Jun/JunBf/f: light gray, Jun/JunBf/fLanDTR: dark gray, DKO*: white, and DKO* LanDTR: black. Data information: Flow cytometric quantifications are depicted as percentage of live cells. Data represent mean ± SEM. Data for (B), (G), and (H) were analyzed using Wilcoxon signed‐rank test, and for (E) and (F), using Mann–Whitney U‐test (*P < 0.05, **P < 0.01, ***P < 0.001). P‐values for this figure are available in Supplementary Table S3. Source data are available online for this figure. Elisabeth Glitzner et al. EMBO Mol Med. 2014;6:1312-1327 © as stated in the article, figure or figure legend