High Frequency of Loss of Heterozygosity on Chromosome Region 9p21–p22 but Lack of p16INK4a/p19ARF Mutations in Greek Patients with Basal Cell Carcinoma.

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High Frequency of Loss of Heterozygosity on Chromosome Region 9p21–p22 but Lack of p16INK4a/p19ARF Mutations in Greek Patients with Basal Cell Carcinoma of the Skin Zacharenia Saridaki, George Sourvinos, Demetrios A. Spandidos Journal of Investigative Dermatology Volume 115, Issue 4, Pages 719-725 (October 2000) DOI: 10.1046/j.1523-1747.2000.00098.x Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Representative examples of LOH detected in BCC. N, normal DNA; T, tumor DNA. Arrows indicate the position of a deleted allele. The faint bands in the position of the deleted alleles are interpreted as contamination by the adjacent normal tissue. Journal of Investigative Dermatology 2000 115, 719-725DOI: (10.1046/j.1523-1747.2000.00098.x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Location of the eight markers on chromosome arm 9p and pattern of LOH in 10 cases. (•, LOH; ○, heterozygosity; , noninformative or no data.) Journal of Investigative Dermatology 2000 115, 719-725DOI: (10.1046/j.1523-1747.2000.00098.x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Location of the eight markers on chromosome arm 9p and pattern of LOH in 10 cases. (•, LOH; ○, heterozygosity; , noninformative or no data.) Journal of Investigative Dermatology 2000 115, 719-725DOI: (10.1046/j.1523-1747.2000.00098.x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Location of the four markers on chromosome arms 17p and 17q and pattern of LOH in 10 cases. •, LOH; ○, heterozygosity; , noninformative or no data. Journal of Investigative Dermatology 2000 115, 719-725DOI: (10.1046/j.1523-1747.2000.00098.x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Location of the four markers on chromosome arms 17p and 17q and pattern of LOH in 10 cases. •, LOH; ○, heterozygosity; , noninformative or no data. Journal of Investigative Dermatology 2000 115, 719-725DOI: (10.1046/j.1523-1747.2000.00098.x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Comparison of sequencing (anti-sense strand) electrophorograms of two samples. Sample 75 is heterozygous for a G/A polymorphism (shown as a C/T in the anti-sense strand) whereas sample 80 lacks this polymorphism. Journal of Investigative Dermatology 2000 115, 719-725DOI: (10.1046/j.1523-1747.2000.00098.x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions