Preventing Primate Gvhd Using a Novel Antagonistic Anti-CD28 Antibody Plus Rapamycin: Downregulation of CD8 Proliferation Predicts Gvhd-Free Survival

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Presentation transcript:

Preventing Primate Gvhd Using a Novel Antagonistic Anti-CD28 Antibody Plus Rapamycin: Downregulation of CD8 Proliferation Predicts Gvhd-Free Survival Benjamin K. Watkins, MD, Nicolas Poirier, Caroline Mary, Gilles Blancho, Karnail Singh, PhD, Aneesah Garrett, Kelly Hamby, Taylor Deane, Bruce R. Blazar, MD, Bernard Vanhove, PhD, Leslie S. Kean, MD, PhD Biology of Blood and Marrow Transplantation Volume 20, Issue 2, (February 2014) DOI: 10.1016/j.bbmt.2013.12.061 Copyright © 2014 Terms and Conditions

Figure 1 Improved GHVD-free Survival by Blocking CD28 Biology of Blood and Marrow Transplantation 2014 20, DOI: (10.1016/j.bbmt.2013.12.061) Copyright © 2014 Terms and Conditions

Figure 2 CD28-blockade-mediated Inhibition of GVHD Correlates with Control of CD8+ T cell Proliferation. A. % of Proliferating CD8+ T cells Measured Longitudinally Post-transplant. B. Inhibition of CD8+ proliferation correlates with GVHD-free survival. Biology of Blood and Marrow Transplantation 2014 20, DOI: (10.1016/j.bbmt.2013.12.061) Copyright © 2014 Terms and Conditions