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IL-12hi Rapamycin-Conditioned Dendritic Cells Mediate IFN-γ-Dependent and Fas- Supported Apoptosis of Alloreactive CD4+ T Cells and Inhibit Graft-Versus-Host.

Published byHilja Haavisto Modified over 5 years ago

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Presentation on theme: "IL-12hi Rapamycin-Conditioned Dendritic Cells Mediate IFN-γ-Dependent and Fas- Supported Apoptosis of Alloreactive CD4+ T Cells and Inhibit Graft-Versus-Host."— Presentation transcript:

1 IL-12hi Rapamycin-Conditioned Dendritic Cells Mediate IFN-γ-Dependent and Fas- Supported Apoptosis of Alloreactive CD4+ T Cells and Inhibit Graft-Versus-Host Disease  Elizabeth Stenger, MD, Brian Rosborough, PhD, Lisa Mathews, Hui Hui Ma, MD PhD, Markus Y. Mapara, MD, PhD, Angus W. Thomson, PhD, Heth Turnquist, PhD  Biology of Blood and Marrow Transplantation  Volume 20, Issue 2, Pages S281-S283 (February 2014) DOI: /j.bbmt Copyright © Terms and Conditions

2 *denotes p<0.05 Figure 3. Autologous IL-12hi RAPA-DC significantly prolong survival from acute GVHD. Biology of Blood and Marrow Transplantation  , S281-S283DOI: ( /j.bbmt ) Copyright © Terms and Conditions

3 *denotes p<0.05 compared to untreated GVHD
1Median survival Figure 2. Apoptosis induced by IL-12hi RAPA-DC is dependent on T cell but not DC responses to IFN-γ and on IL-12 expression. Biology of Blood and Marrow Transplantation  , S281-S283DOI: ( /j.bbmt ) Copyright © Terms and Conditions

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