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A First-in-Disease Trial of in Vivo Costimulation Blockade for GVHD Prevention: The Addition of Abatacept to Standard GVHD Prophylaxis Controls Early.

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Presentation on theme: "A First-in-Disease Trial of in Vivo Costimulation Blockade for GVHD Prevention: The Addition of Abatacept to Standard GVHD Prophylaxis Controls Early."— Presentation transcript:

1 A First-in-Disease Trial of in Vivo Costimulation Blockade for GVHD Prevention: The Addition of Abatacept to Standard GVHD Prophylaxis Controls Early CD4+ T Cell Proliferation and is Associated with Low Rates of Severe Acute GVHD  Divya Tiwari, John Horan, Amelia Langston, Muna Qayed, Jennifer Carr, Heather Renfroe, Cynthia Couture, H. Jean Khoury, Jennifer Robertson, D. Harvey, Aneesh Mehta, Edmund K. Waller, Leslie S. Kean  Biology of Blood and Marrow Transplantation  Volume 19, Issue 2, Pages S327-S328 (February 2013) DOI: /j.bbmt Copyright © Terms and Conditions

2 Figure 1A Patients Treated with Abatacept Exhibit Fewer Proliferating CD4+ T Cells After Transplant. Black: Control patients treated with cyclosporine/MTX alone (n=6), Red: Patients treated with cyclosporine/MTX + Abatacept (n = 10) Biology of Blood and Marrow Transplantation  , S327-S328DOI: ( /j.bbmt ) Copyright © Terms and Conditions

3 Figure 1B Cumulative Incidence of Grade II-IV aGvHD (left) and Gr III-IV aGvHD (right) In Patients Through Day +100 on the Abatacept Trial. No Grade IV aGvHD developed. Biology of Blood and Marrow Transplantation  , S327-S328DOI: ( /j.bbmt ) Copyright © Terms and Conditions

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