Sarah M. Brant, MD, Michael L. Cobert, PhD, LaShondra M

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Characterizing Cardiac Donation After Circulatory Death: Implications for Perfusion Preservation Sarah M. Brant, MD, Michael L. Cobert, PhD, LaShondra M. West, MS, John M. Shelton, BS, Michael E. Jessen, MD, Matthias Peltz, MD The Annals of Thoracic Surgery Volume 98, Issue 6, Pages 2107-2114 (December 2014) DOI: 10.1016/j.athoracsur.2014.05.091 Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Rate-pressure product during agonal phase. Values are mean ± standard error of the mean (SEM). ∗p < 0.05 compared with baseline. The Annals of Thoracic Surgery 2014 98, 2107-2114DOI: (10.1016/j.athoracsur.2014.05.091) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Oxygen consumption (MV˙o2; black line and symbols) and lactate levels (gray line and symbols) during retrograde machine perfusion. Values are mean ± standard error of the mean (SEM). ∗p < 0.05 MV˙o2 compared with 0.5 hour. The Annals of Thoracic Surgery 2014 98, 2107-2114DOI: (10.1016/j.athoracsur.2014.05.091) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Preload recruitable stroke work (PRSW) during reperfusion for perfused (black line and symbols) and static (gray line and symbols) groups. Values are mean ± standard error of the mean (SEM). ∗p < 0.05 compared with static. †p < 0.05 static compared with baseline. The Annals of Thoracic Surgery 2014 98, 2107-2114DOI: (10.1016/j.athoracsur.2014.05.091) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Cardiac enzyme levels after 6 hours of reperfusion for perfused and static groups. (A) Total creatine kinase; (B) Troponin T. Values are mean ± standard error of the mean (SEM). ∗p < 0.05 compared with perfused. †p < 0.16 compared with perfused. The Annals of Thoracic Surgery 2014 98, 2107-2114DOI: (10.1016/j.athoracsur.2014.05.091) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Myocardial cell death as determined by terminal deoxynucleotidyl transferase-mediated UTP nick end label (TUNEL) assay in perfused and static groups. Values are mean ± standard error of the mean (SEM). ∗p < 0.05 compared with static. The Annals of Thoracic Surgery 2014 98, 2107-2114DOI: (10.1016/j.athoracsur.2014.05.091) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions