Testosterone and Erectile Function: From Basic Research to a New Clinical Paradigm for Managing Men with Androgen Insufficiency and Erectile Dysfunction

Slides:

Advertisements

Similar presentations

The Origin of the Bone Scan as a Tumour Marker in Prostate Cancer

Advertisements

Testosterone Therapy in Men With Prostate Cancer

Volume 65, Issue 1, Pages (January 2014)

Shifting the Paradigm of Testosterone and Prostate Cancer: The Saturation Model and the Limits of Androgen-Dependent Growth Abraham Morgentaler, Abdulmaged.

Vein wall re-endothelialization after deep vein thrombosis is improved with low- molecular-weight heparin Daria K. Moaveni, MD, Erin M. Lynch, MS, Cathy.

Volume 62, Issue 4, Pages (October 2012)

Volume 67, Issue 4, Pages (April 2015)

Nuclear Accumulation of Histone Deacetylase 4 (HDAC4) Coincides with the Loss of Androgen Sensitivity in Hormone Refractory Cancer of the Prostate K.

Volume 4, Issue 3, Pages (June 2006)

Testosterone and Prostate Cancer: Revisiting Old Paradigms

Therapeutic angiogenesis using autologous bone marrow stromal cells: improved blood flow in a chronic limb ischemia model Abdulaziz Al-Khaldi, MD, Hilal.

Volume 46, Issue 3, Pages (September 2004)

Urethra Reconstruction Following Resection of Penile Leiomyosarcoma

Volume 123, Issue 5, Pages (November 2002)

Volume 55, Issue 2, Pages (February 2009)

Sustained orbital shear stress stimulates smooth muscle cell proliferation via the extracellular signal-regulated protein kinase 1/2 pathway Hidenori.

Volume 70, Issue 6, Pages (December 2016)

Volume 54, Issue 1, Pages (July 2008)

The Relationship between Erectile Dysfunction and Lower Urinary Tract Symptoms and the Role of Phosphodiesterase Type 5 Inhibitors Tobias S. Köhler,

Volume 63, Issue 3, Pages (March 2013)

Volume 62, Issue 6, Pages (December 2012)

Let the Games Begin (with EAU Approval)

Volume 57, Issue 2, Pages (February 2010)

Volume 52, Issue 3, Pages (September 2007)

Volume 57, Issue 6, Pages (June 2010)

Volume 56, Issue 2, Pages (August 2009)

John P. Mulhall, Francesco Montorsi European Urology

Daily Administration of Phosphodiesterase Type 5 Inhibitors for Urological and Nonurological Indications Anthony J. Bella, Ling X. DeYoung, Mussa al-Numi,

Cholinergic Innervation and Muscarinic Receptors in the Human Prostate

Angelo J. Cambio, Christopher P. Evans European Urology

Physiology of the endothelium

Volume 58, Issue 5, Pages (November 2010)

Androgen Receptor Variants and Castration-resistant Prostate Cancer: Looking Back and Looking Forward Takuma Uo, Cynthia Sprenger European Urology

Adeno-associated Virus Serotype Vectors Efficiently Transduce Normal Prostate Tissue and Prostate Cancer Cells Jianzhong Ai, Dan Wang, Qiang Wei, Hong.

Volume 71, Issue 1, Pages 1-3 (January 2017)

Volume 54, Issue 6, Pages (December 2008)

The Distribution of Estrogen Receptor β Is Distinct to That of Estrogen Receptor α and the Androgen Receptor in Human Skin and the Pilosebaceous Unit

Volume 63, Issue 3, Pages (March 2013)

Volume 50, Issue 3, Pages (September 2006)

The Origin of the Bone Scan as a Tumour Marker in Prostate Cancer

Volume 61, Issue 1, Pages (January 2012)

Shifting Paradigms for High-grade Prostatic Intraepithelial Neoplasia

Volume 56, Issue 4, Pages (October 2009)

Testosterone Measurement in Patients with Prostate Cancer

Michèle Algarté-Génin, Olivier Cussenot, Pierre Costa European Urology

Volume 54, Issue 6, Pages (December 2008)

Volume 50, Issue 5, Pages (November 2006)

Volume 53, Issue 6, Pages (June 2008)

CyberKnife in the Treatment of Prostate Cancer: A Revolutionary System

Adenovirus-mediated intra-arterial delivery of cellular repressor of E1A-stimulated genes inhibits neointima formation in rabbits after balloon injury

Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury Lihong Fan, MD, Kunzheng.

Optimal Control of Testosterone: A Clinical Case-Based Approach of Modern Androgen- Deprivation Therapy Bertrand Tombal, Richard Berges European Urology.

Volume 59, Issue 4, Pages (April 2001)

Volume 140, Issue 3, Pages e4 (March 2011)

Christian Stief European Urology Supplements

European Urology is “Your” Journal

Gabriele Di Luozzo, MD, Jaya Bhargava, PhD, Richard J. Powell, MD

Volume 70, Issue 10, Pages (November 2006)

Volume 140, Issue 3, Pages e4 (March 2011)

Proposed Mechanism for the Efficacy of Injected Botulinum Toxin in the Treatment of Human Detrusor Overactivity Apostolos Apostolidis, Prokar Dasgupta,

Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthma Annelies M. Slats, MD, Kirsten Janssen, BHe, Annemarie.

Evaluation and Medical Management of Erectile Dysfunction

Renin–angiotensin system blockade and diabetes: moving the adipose organ from the periphery to the center Oliver Lenz, Alessia Fornoni Kidney International

Fig. 2. Proinflammatory response of macrophages may exacerbate mitochondrial dysfunction in adipocytes. In addition to the primary mitochondrial dysfunction.

The Modulation of Aromatase and Estrogen Receptor Alpha in Cultured Human Dermal Papilla Cells by Dexamethasone: A Novel Mechanism for Selective Action.

Hedgehog signaling plays a conserved role in inhibiting fat formation

Richard J. Sanders, MD 1, William H. Pearce, MD 2

Volume 6, Issue 4, Pages (April 2004)

Volume 51, Issue 5, Pages (May 2007)

Evaluation and Medical Management of Erectile Dysfunction

Presentation transcript:

Testosterone and Erectile Function: From Basic Research to a New Clinical Paradigm for Managing Men with Androgen Insufficiency and Erectile Dysfunction Abdulmaged M. Traish, Irwin Goldstein, Noel N. Kim European Urology Volume 52, Issue 1, Pages 54-70 (July 2007) DOI: 10.1016/j.eururo.2007.02.034 Copyright © 2007 European Association of Urology Terms and Conditions

Fig. 1 Effect of androgens on rat penile cavernosal nerve structure. Tissue sections of cavernosal nerves from intact (sham-operated) or castrated rats were fixed in glutaraldehyde and stained with toluidine blue to visualize myelinated nerve fibers (magnification=1000×, oil immersion). Castrated rats infused with vehicle (B) exhibited decreased nerve fiber density and thinner myelin sheaths compared with intact rats (A) or castrated rats infused with testosterone (C). Myelinated nerve fibers can be seen throughout each section and appear as darkened circular or irregularly shaped profiles. European Urology 2007 52, 54-70DOI: (10.1016/j.eururo.2007.02.034) Copyright © 2007 European Association of Urology Terms and Conditions

Fig. 2 Potential regulation of nitric oxide synthase (NOS) and phosphodiesterase (type) 5 (PDE5) by androgens. Hypothetical mechanism by which androgens may upregulate both NOS and PDE5 proteins. European Urology 2007 52, 54-70DOI: (10.1016/j.eururo.2007.02.034) Copyright © 2007 European Association of Urology Terms and Conditions

Fig. 3 Proposed mechanism of regulation of cellular differentiation by androgens in penile corpus cavernosum. Androgens, through the activation of androgen receptors (ARs), may stimulate stromal precursor cells to differentiate into smooth muscle cells (solid lines/arrows). Normal smooth muscle cell content is predicted to result in abundant amounts of smooth muscle marker proteins (α-actin, desmin, laminin, myosin, vinculin) and decreased levels of adipocyte marker proteins (C/EBPα [CCAAT/enhancer binding protein], PPARγ2 [peroxisome proliferator-activated receptor], and LPL [lipoprotein lipase]). Androgen deprivation may inhibit the smooth muscle differentiation pathway and stimulate differentiation of stromal precursor cells into adipocytes and/or transdifferentiation of smooth muscle cells (dashed lines/arrows). Either of these states is predicted to result in increased levels of adipogenic markers and decreased levels of smooth muscle marker proteins. European Urology 2007 52, 54-70DOI: (10.1016/j.eururo.2007.02.034) Copyright © 2007 European Association of Urology Terms and Conditions

Fig. 4 Diagnosis and treatment algorithm for androgen insufficiency and erectile dysfunction. European Urology 2007 52, 54-70DOI: (10.1016/j.eururo.2007.02.034) Copyright © 2007 European Association of Urology Terms and Conditions