Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: Phosphorus 31—nuclear magnetic resonance measurements.

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Presentation transcript:

Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: Phosphorus 31—nuclear magnetic resonance measurements of intracellular pH and cellular energy Akira Koike, MDa, Toshiaki Akita, MDa, Yoshihiro Hotta, PhDb, Kazumi Takeya, PhDb, Itsuo Kodama, MDc, Mitsuya Murase, MDa, Toshio Abe, MDa, Junji Toyama, MDc The Journal of Thoracic and Cardiovascular Surgery Volume 112, Issue 3, Pages 765-775 (September 1996) DOI: 10.1016/S0022-5223(96)70063-6 Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 31P-NMR spectra obtained from an untreated (control) rabbit heart before ischemia, during ischemia, and during reperfusion. Numbered peaks are as follows: 1, methylene diphosphate; 2, intracellular Pi; 3, PCr; 4, 5, and 6, γ-, α-, and β-phosphate group of ATP, respectively. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 765-775DOI: (10.1016/S0022-5223(96)70063-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Changes in the left ventricular end-diastolic pressure (LVEDP) during 45 minutes of ischemia and subsequent 50 minutes of reperfusion. Left ventricular end-diastolic pressure is plotted as a function of time. Zero time is the beginning of cardioplegia and the beginning of reperfusion. Values are presented in means ± standard error of six untreated hearts (control, open circles) and eight hearts treated with DMA at 10 μmol/L (closed circles). *Significantly different from control at p < 0.05. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 765-775DOI: (10.1016/S0022-5223(96)70063-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 3 Changes in the left ventricular systolic pressure (LVSP), developed pressure (LVDP), and maximum rate of contraction and relaxation (±dp/dt) during 45 minutes of ischemia and a subsequent 50 minutes of reperfusion. The hemodynamic parameters are plotted as a function of time. Zero time is the beginning of cardioplegia and the beginning of reperfusion. Values are means ± standard error of six untreated hearts (control, open circles) and of eight hearts treated with DMA at 10 μmol/L (closed circles). *Significantly different from control at p < 0.05. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 765-775DOI: (10.1016/S0022-5223(96)70063-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 4 Changes in pHi during 45 minutes of ischemia and a subsequent 30 minutes of reperfusion. Ordinate indicates pHi calculated from the chemical shift of Pi peak from PCr peak in 31P-NMR spectra. Abscissa is time (in minutes) after the initiation of cardioplegia with St. Thomas' Hospital cardioplegic solution and after the initiation of reperfusion. Values are means ± standard error of the mean of six untreated hearts (control, open circles) and eight hearts treated with DMA at 10 μmol/L (closed circles). *Significantly different from control at p < 0.05. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 765-775DOI: (10.1016/S0022-5223(96)70063-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 5 Changes in high-energy phosphates during 45 minutes of ischemia and a subsequent 30 minutes of reperfusion. Ordinates indicate PCr in A, Pi in B, and ATP in C. Abscissas indicate time (in minutes) after the initiation of cardioplegia with St. Thomas' Hospital cardioplegic solution and after the initiation of reperfusion. PCr and ATP were expressed as a percentage relative to the preischemic baseline. Pi was expressed as a percentage of the sum of phosphate from PCr, ATP, and Pi during the preischemic baseline period. Values are means ± standard error of the mean of six untreated hearts (control, open circles) and eight hearts treated with DMA at 10 μmol/L (closed circles). The Journal of Thoracic and Cardiovascular Surgery 1996 112, 765-775DOI: (10.1016/S0022-5223(96)70063-6) Copyright © 1996 Mosby, Inc. Terms and Conditions