Efficacy and Safety of Thrombin-Receptor Antagonist (Atopaxar and Vorapaxar) in Patients with Acute Coronary Syndrome or Coronary Artery Disease—A Meta-Analysis.

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Presentation transcript:

Efficacy and Safety of Thrombin-Receptor Antagonist (Atopaxar and Vorapaxar) in Patients with Acute Coronary Syndrome or Coronary Artery Disease—A Meta-Analysis of Randomized Controlled Trials  Lan Gao, PhD, Fei-Li Zhao, PhD, MPH, Shu-Chuen Li, PhD, MBA  Value in Health Regional Issues  Volume 6, Pages 22-32 (May 2015) DOI: 10.1016/j.vhri.2015.01.003 Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions

Fig. 1 Study selection process. RCT, randomized controlled trial. Value in Health Regional Issues 2015 6, 22-32DOI: (10.1016/j.vhri.2015.01.003) Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions

Fig. 2 Pooled efficacy effects (TRA vs placebo) for patients with ACS. ACS, acute coronary syndrome; CI, confidence interval; CV, cardiovascular; MACE, major adverse cardiovascular event; MI, myocardial infarction; TRA, thrombin-receptor antagonist. Value in Health Regional Issues 2015 6, 22-32DOI: (10.1016/j.vhri.2015.01.003) Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions

Fig. 3 Pooled safety effects (TRA vs placebo) for patients with ACS. ACS, acute coronary syndrome; CI, confidence interval; TIMI, thrombolysis in myocardial infarction; TRA, thrombin-receptor antagonist. Value in Health Regional Issues 2015 6, 22-32DOI: (10.1016/j.vhri.2015.01.003) Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions

Fig. 4 Pooled efficacy effects (TRA vs placebo) for patients with CAD. CAD, coronary artery disease; CI, confidence interval; CV, cardiovascular; MACE, major adverse cardiovascular event; MI, myocardial infarction; TRA, thrombin-receptor antagonist. Value in Health Regional Issues 2015 6, 22-32DOI: (10.1016/j.vhri.2015.01.003) Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions

Fig. 5 Pooled safety effects (TRA vs placebo) for patients with CAD. CAD, coronary artery disease; CI, confidence interval; TIMI, thrombolysis in myocardial infarction; TRA, thrombin-receptor antagonist. Value in Health Regional Issues 2015 6, 22-32DOI: (10.1016/j.vhri.2015.01.003) Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions

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