Predictors of acute throat or esophageal patient reported pain during radiation therapy for head and neck cancer Hiram A. Gay, Jung Hun Oh, Aditya P.

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Predictors of acute throat or esophageal patient reported pain during radiation therapy for head and neck cancer Hiram A. Gay, Jung Hun Oh, Aditya P. Apte, Mackenzie D. Daly, Douglas R. Adkins, Jason Rich, Peter J. Oppelt, Pawel T. Dyk, Daniel F. Mullen, Laura Eschen, Re-I. Chin, Brian Nussenbaum, Bruce H. Haughey, Wade L. Thorstad, Joseph O. Deasy Clinical and Translational Radiation Oncology Volume 13, Pages 1-6 (November 2018) DOI: 10.1016/j.ctro.2018.08.004 Copyright © 2018 The Authors Terms and Conditions

Fig. 1 Average maximum pain score at each week after the start of radiotherapy for (A) esophagus pain and (B) throat pain. The error bar indicates the standard error. Clinical and Translational Radiation Oncology 2018 13, 1-6DOI: (10.1016/j.ctro.2018.08.004) Copyright © 2018 The Authors Terms and Conditions

Fig. 2 Fractional mean dose in the esophagus for esophagus pain and in the oral cavity for throat pain as a function of maximum pain scores. The error bar indicates the standard error. Clinical and Translational Radiation Oncology 2018 13, 1-6DOI: (10.1016/j.ctro.2018.08.004) Copyright © 2018 The Authors Terms and Conditions

Fig. 3 Patients were dichotomized into lower pain (score: 0 or 1) and higher pain (score: 2 or 3) groups. Logistic regression analysis resulted in odds ratio = 3.1 (95% confidence interval [CI]: 1.2–7.9; p = 0.015) and odds ratio = 10.2 (95% CI: 3.6–29.2; p < 0.001) for esophagus pain and throat pain, respectively. This means that for each increase in 1 Gy of fractional organ at risk mean dose, the estimated odds of experiencing higher pain increase by a factor of 3.1 and 10.2, respectively. Clinical and Translational Radiation Oncology 2018 13, 1-6DOI: (10.1016/j.ctro.2018.08.004) Copyright © 2018 The Authors Terms and Conditions

Fig. 4 Comparison of fractional mean dose (A) in esophagus for esophagus pain and (B) in oral cavity for throat pain between surgical and non-surgical groups. The error bar indicates the standard deviation. Clinical and Translational Radiation Oncology 2018 13, 1-6DOI: (10.1016/j.ctro.2018.08.004) Copyright © 2018 The Authors Terms and Conditions