MAGE qPCR Improves the Sensitivity and Accuracy of EBUS-TBNA for the Detection of Lymphatic Cancer Spread Beatrix Cucuruz, MD, Sebastian Dango, MD, Vindi.

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MAGE qPCR Improves the Sensitivity and Accuracy of EBUS-TBNA for the Detection of Lymphatic Cancer Spread Beatrix Cucuruz, MD, Sebastian Dango, MD, Vindi Jurinovic, MSc, Olga Mayer, Marie Follo, PhD, Joachim Böhm, MD, Nikolaus Freudenberg, MD, Mirjam Elze, MD, Wulf Sienel, MD, Christoph A. Klein, MD, Bernward Passlick, MD, Bernhard Polzer, MD Journal of Thoracic Oncology Volume 7, Issue 4, Pages 690-697 (April 2012) DOI: 10.1097/JTO.0b013e31824294de Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 Study design. The flow chart describes the diagnostic procedures used for a mediastinal lymph node analysis of lung cancer patients. To prevent false-negative results, patients with negative endobronchial ultrasound-guided fine-needle aspiration were subjected to mediastinoscopy, and patients with negative mediastinoscopy were treated by surgical resection. Journal of Thoracic Oncology 2012 7, 690-697DOI: (10.1097/JTO.0b013e31824294de) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

Figure 2 Comparison between quantitative melanoma antigens 1–6 and melanoma antigens 12 expression. The relative quantification values of melanoma antigens 1–6 and 12 gene expression were plotted against each other on a logarithmic scale for endobronchial ultrasound-guided fine-needle aspiration samples (A, Spearman's [rho] correlation coefficient, r = 0.422; p < 0.001) and mediastinoscopy samples (B, Spearman's [rho] correlation coefficient r = 0.257; p = 0.004). Journal of Thoracic Oncology 2012 7, 690-697DOI: (10.1097/JTO.0b013e31824294de) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

Figure 3 Mediastinal lymph node metastasis of a squamous carcinoma of the lung. A, Histological specimen showing compact formations of tumor cells (⋆) within a desmoplastic stroma containing few rests of lymphatic tissue (L). Hematoxylin and eosin (HE)staining, 100-fold magnification. B, Cell cluster of an endobronchial ultrasound-guided fine-needle aspiration specimen with a group of tumor cells adjacent to residual lymphocytes of the lymph node. Note intracellular keratinization in one of the tumor cells (⇓). HE staining of the liquid-based cytology, 200-fold magnification. Journal of Thoracic Oncology 2012 7, 690-697DOI: (10.1097/JTO.0b013e31824294de) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions