Adenomyosis: a life-cycle approach Giuseppe Benagiano, Ivo Brosens, Marwan Habiba  Reproductive BioMedicine Online  Volume 30, Issue 3, Pages 220-232 (March 2015) DOI: 10.1016/j.rbmo.2014.11.005 Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Ultrasound images of a uterus with adenomyosis. Panel A: grey scale image showing asymmetrically thickened posterior uterine wall with inhomogeneous, irregular myometrial echotexture with hyperechoic irregular myometrial areas and small cystic anechoic areas; panel B: power Doppler image showing diffusely spread small vessels (white arrow). (Courtesy of Dr. Caterina Exacoustos, Rome). Reproductive BioMedicine Online 2015 30, 220-232DOI: (10.1016/j.rbmo.2014.11.005) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Ultrasound image of the uterus obtained using three-dimensional ultrasound and volume contrast imaging (VCI) with 4-mm slices. The multiplanar view shows transverse and coronal sections of the uterus on the left side of the image; a longitudinal section is shown on the right side of the image. Note the round cystic anechoic areas (white arrows) in the myometrium below the endometrium in the junctional zone. The coronal view of the uterus is shown with the junctional zone appearing as a dark halo outside the endometrium on the right and left side of the endometrial cavity (yellow arrow) and with distortion and infiltration by hyperechoic endometrial tissue on the fundus and left side of the image (red arrows). (Courtesy of Dr. Caterina Exacoustos, Rome). Reproductive BioMedicine Online 2015 30, 220-232DOI: (10.1016/j.rbmo.2014.11.005) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Figure 3 Age distribution of 210 patients with adenomyosis at hysterectomy. Adapted from Emge (1962). Reproductive BioMedicine Online 2015 30, 220-232DOI: (10.1016/j.rbmo.2014.11.005) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions