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Risks of adverse pregnancy outcome in endometriosis

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1 Risks of adverse pregnancy outcome in endometriosis
Ivo Brosens, M.D., Ph.D., Jan J. Brosens, M.D., Ph.D., Luca Fusi, M.D., Marwa Al-Sabbagh, Ph.D., Keiji Kuroda, M.D., Ph.D., Giuseppe Benagiano, M.D., Ph.D.  Fertility and Sterility  Volume 98, Issue 1, Pages (July 2012) DOI: /j.fertnstert Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Transformation of the endometrium and junctional zone in the nonpregnant uterus into the placental bed of pregnancy. (A) T2-weighted midsagittal MRI showing that the junctional zone (dotted line) is irregular and thickened in the posterior uterine wall. (B) Low-magnification histological section through the endometrium and junctional zone. Note that the basal endometrial glands penetrate the junctional zone. (C) Full-thickness section through the fetomaternal interface around 10 weeks of gestation. Note the highly dilated secretory glands in the decidual portion of the placental bed. (D) Remodeling of the junctional zone segment of transversing spiral arteries in the placental bed. The upper panel shows a fully transformed low-resistance, high-capacity vessel in normal pregnancy at 38 weeks' gestation. The lower panel is a micrograph of an untransformed spiral artery with evidence of acute atherosis in a patient with chronic hypertension and superimposed preeclampsia and fetal growth restriction. Note the presence of interstitial trophoblast in the junctional zone surrounding the spiral artery. The tissue sections were stained with Masson trichrome. Fertility and Sterility  , 30-35DOI: ( /j.fertnstert ) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions


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