Independent Control of Aging and Axon Regeneration

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Presentation transcript:

Independent Control of Aging and Axon Regeneration Stephane Belin, Michael Norsworthy, Zhigang He Cell Metabolism Volume 19, Issue 3, Pages 354-356 (March 2014) DOI: 10.1016/j.cmet.2014.02.014 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 The Signaling Pathways Regulating Life Span and Regeneration Both daf-2/insulin receptor and daf-18/PTEN-mTOR impact animals’ life spans. However, daf-2/insulin receptor inhibits age-dependent axon regeneration via a daf-16/FOXO-DLK pathway, and daf-18/PTEN-mTOR regulates axon regeneration in both young and aging animals. The interactions of these pathways in coordinating neuronal responses to axonal insults remain unknown. Cell Metabolism 2014 19, 354-356DOI: (10.1016/j.cmet.2014.02.014) Copyright © 2014 Elsevier Inc. Terms and Conditions