Prolonged mild hypothermia after experimental hypothermic circulatory arrest in a chronic porcine model Pekka Romsi, MDa, Janne Heikkinen, MSa, Fausto.

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Prolonged mild hypothermia after experimental hypothermic circulatory arrest in a chronic porcine model Pekka Romsi, MDa, Janne Heikkinen, MSa, Fausto Biancari, MD, PhDa, Matti Pokela, MSa, Jussi Rimpiläinen, MD, PhDa, Vilho Vainionpää, MD, PhDb, Jorma Hirvonen, MD, PhDc, Ville Jäntti, MD, PhDd, Kai Kiviluoma, MD, PhDb, Vesa Anttila, MD, PhDa, Tatu Juvonen, MD, PhDa The Journal of Thoracic and Cardiovascular Surgery Volume 123, Issue 4, Pages 724-734 (April 2002) DOI: 10.1067/mtc.2002.119069 Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Epidural temperatures in pigs during the experimental protocol. Values are expressed as medians and interquartile ranges (25th-75th percentile). The Journal of Thoracic and Cardiovascular Surgery 2002 123, 724-734DOI: (10.1067/mtc.2002.119069) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Daily score indicating behavioral recovery after 75 minutes of HCA. A score of 8 or 9 indicates essentially complete recovery. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 724-734DOI: (10.1067/mtc.2002.119069) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Cardiac index and oxygen kinetics parameters. Values are expressed as medians with interquartile ranges (25th-75th percentile). *P <.05, interaction between time versus baseline and other intervals in the study groups; **P <.01, interaction between time versus baseline and other intervals in the study groups. Svo2, Mixed venous oxygen saturation. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 724-734DOI: (10.1067/mtc.2002.119069) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Results of brain microdialysis, intracranial pressure, and brain tissue oxygen partial pressure measurements. Values are expressed as medians with interquartile ranges (25th-75th percentile). *P <.05, interaction between time versus baseline and other intervals in the study groups; **P <.01, interaction between time versus baseline and other intervals in the study groups. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 724-734DOI: (10.1067/mtc.2002.119069) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 5 EEG burst recovery in pigs after 75 minutes of HCA. Burst-suppression ratio = [EEG burst time/(EEG burst time + EEG suppression time)] × 100. Heavy black lines, Median; light solid lines, alive at the seventh postoperative day; dashed lines, dead before the seventh postoperative day. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 724-734DOI: (10.1067/mtc.2002.119069) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions