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Leukocyte filtration improves brain protection after a prolonged period of hypothermic circulatory arrest: A study in a chronic porcine model  Jussi Rimpiläinen,

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Presentation on theme: "Leukocyte filtration improves brain protection after a prolonged period of hypothermic circulatory arrest: A study in a chronic porcine model  Jussi Rimpiläinen,"— Presentation transcript:

1 Leukocyte filtration improves brain protection after a prolonged period of hypothermic circulatory arrest: A study in a chronic porcine model  Jussi Rimpiläinen, MDa, Matti Pokela, MSa, Kai Kiviluoma, MD, PhDb, Vesa Anttila, MDa, Vilho Vainionpää, MD, PhDb, Jorma Hirvonen, MD, PhDd, Pasi Ohtonen, MSca, Ari Mennander, MD, PhDa, Elina Remes, MSc, Tatu Juvonen, MD, PhDa  The Journal of Thoracic and Cardiovascular Surgery  Volume 120, Issue 6, Pages (December 2000) DOI: /mtc Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

2 Fig. 1 Epidural temperatures of 20 pigs undergoing CPB with or without an L-DF before and after a 75-minute period of HCA. Values are shown as medians with interquartile range. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

3 Fig. 2 EEG burst recovery of 20 pigs undergoing CPB with or without an L-DF before and after a 75-minute period of HCA. Bold lines indicate medians, and broken lines depict animals with early mortality. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

4 Fig. 3 Daily scores indicating behavioral recovery of 20 pigs undergoing CPB with or without an L-DF before and after a 75-minute period of HCA. A score of 8 or 9 indicates essentially complete recovery; lower scores indicate substantial impairment, and 0 indicates coma or death. P values are given for the difference between groups in score by time. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

5 Fig. 4 Total histopathologic scores of 20 pigs undergoing CPB with or without an L-DF before and after a 75-minute period of HCA. The total histopathologic score was calculated by adding the quantitative assessment of histopathologic findings in the investigated regions of the brain for each of the animals. The scores in the L-DF group were lower than those in the control group (P = .005). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

6 Fig. 5 S-100 protein levels of 20 pigs undergoing CPB with or without an L-DF before and after a 75-minute period of HCA. Medians with interquartile range are shown. There were no statistically significant differences between the groups. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

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