Bone marrow lesions, subchondral bone cysts and subchondral bone attrition are associated with histological synovitis in patients with end-stage knee.

Slides:

Advertisements

Similar presentations

C. G Peterfy, M. D. Ph. D. , A Guermazi, M. D. , S Zaim, M. D. , P. F

Advertisements

Changes in patellofemoral and tibiofemoral joint cartilage damage and bone marrow lesions over 7 years: the Multicenter Osteoarthritis Study J.J. Stefanik,

The role of imaging modalities in the diagnosis, differential diagnosis and clinical assessment of peripheral joint osteoarthritis C.Y.J. Wenham, A.J.

Whole joint MRI assessment of surgical cartilage repair of the knee: Cartilage Repair OsteoArthritis Knee Score (CROAKS) F.W. Roemer, A. Guermazi, S.

B. J. Kim, D. -W. Kim, S. H. Kim, J. H. Cho, H. J. Lee, D. Y. Park, S

Validity and responsiveness of a new measure of knee osteophytes for osteoarthritis studies: data from the osteoarthritis initiative M. Hakky, M. Jarraya,

Atlas of individual radiographic features in osteoarthritis, revised

T1ρ relaxation time of the meniscus and its relationship with T1ρ of adjacent cartilage in knees with acute ACL injuries at 3T R.I. Bolbos, Ph.D., T.M.

Subchondral bone marrow lesions are highly associated with, and predict subchondral bone attrition longitudinally: the MOST study F.W. Roemer, T. Neogi,

Changes in patellofemoral and tibiofemoral joint cartilage damage and bone marrow lesions over 7 years: the Multicenter Osteoarthritis Study J.J. Stefanik,

Imaging following acute knee trauma

T1ρ and T2 relaxation times predict progression of knee osteoarthritis

Predictive validity of within-grade scoring of longitudinal changes of MRI-based cartilage morphology and bone marrow lesion assessment in the tibio-femoral.

Increased risk for radiographic osteoarthritis features in young active athletes: a cross- sectional matched case–control study F.W. Roemer, M. Jarraya,

Regional analysis of femorotibial cartilage loss in a subsample from the Osteoarthritis Initiative progression subcohort W. Wirth, M.S., M.-P. Hellio.

Imaging of non-osteochondral tissues in osteoarthritis

C. G Peterfy, M. D. Ph. D. , A Guermazi, M. D. , S Zaim, M. D. , P. F

Osteoarthritis and Cartilage

ADAMTS5−/− mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage.

Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice S. Hashimoto, M.F. Rai, K.L.

Development and reliability of a multi-modality scoring system for evaluation of disease progression in pre-clinical models of osteoarthritis: celecoxib.

Bone marrow lesions on magnetic resonance imaging in hand osteoarthritis are associated with pain and interact with synovitis R. Liu, W. Damman, M. Reijnierse,

Cyst-like lesions of the knee joint and their relation to incident knee pain and development of radiographic osteoarthritis: the MOST study A. Guermazi,

Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score) D.J. Hunter, A. Guermazi, G.H. Lo, A.J. Grainger,

A.S. Aula, J. Töyräs, V. Tiitu, J.S. Jurvelin

Structural correlates of pain in joints with osteoarthritis

L. A. MacFarlane, H. Yang, J. E. Collins, A. Guermazi, M. H. Jones, E

Volumetric and semiquantitative assessment of MRI-detected subchondral bone marrow lesions in knee osteoarthritis: a comparison of contrast-enhanced and.

Presence, location, type and size of denuded areas of subchondral bone in the knee as a function of radiographic stage of OA – data from the OA initiative

Whole joint MRI assessment of surgical cartilage repair of the knee: Cartilage Repair OsteoArthritis Knee Score (CROAKS) F.W. Roemer, A. Guermazi, S.

S. Reichenbach, M. D. , A. Guermazi, M. D. , J. Niu, M. B. B. S. , D

The chemokine receptor CCR5 plays a role in post-traumatic cartilage loss in mice, but does not affect synovium and bone K. Takebe, M.F. Rai, E.J. Schmidt,

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the rat N. Gerwin, A.M. Bendele, S. Glasson,

Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice A. Cai, E. Hutchison,

M. K. Javaid, J. A. Lynch, I. Tolstykh, A. Guermazi, F. Roemer, P

M. A. McNulty, R. F. Loeser, C. Davey, M. F. Callahan, C. M

Use of routine clinical multimodality imaging in a rabbit model of osteoarthritis – part I M. Bouchgua, D.M.V., K. Alexander, D.M.V., M.Sc., Dipl. A.C.V.R.,

Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity J.P.

Is increased joint loading detrimental to obese patients with knee osteoarthritis? A secondary data analysis from a randomized trial M. Henriksen, D.J.

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the dog J.L. Cook, K. Kuroki, D. Visco, J.-P.

D. Hayashi, F.W. Roemer, A. Guermazi Osteoarthritis and Cartilage

Integrin α1β1 protects against signs of post-traumatic osteoarthritis in the female murine knee partially via regulation of epidermal growth factor receptor.

Pre-radiographic osteoarthritic changes are highly prevalent in the medial patella and medial posterior femur in older persons: Framingham OA study D.

The degeneration and destruction of femoral articular cartilage shows a greater degree of deterioration than that of the tibial and patellar articular.

Joint loading and proximal tibia subchondral trabecular bone microarchitecture differ with walking gait patterns in end-stage knee osteoarthritis B.C.

Bone marrow lesions and joint effusion are strongly and independently associated with weight-bearing pain in knee osteoarthritis: data from the osteoarthritis.

Rates and sensitivity of knee cartilage thickness loss in specific central reading radiographic strata from the osteoarthritis initiative S. Maschek,

Structural changes in the knee during weight loss maintenance after a significant weight loss in obese patients with osteoarthritis: a report of secondary.

Comments on Beattie et al

K. Kuroki, C.R. Cook, J.L. Cook Osteoarthritis and Cartilage

Magnetic resonance imaging (MRI)-defined cartilage degeneration and joint pain are associated with poor physical function in knee osteoarthritis – the.

Comparison of BLOKS and WORMS scoring systems part I

Temporal assessment of bone marrow lesions on magnetic resonance imaging in a canine model of knee osteoarthritis: impact of sequence selection M.-A.

Associations between MRI-detected early osteophytes and knee structure in older adults: a population-based cohort study Z. Zhu, L.L. Laslett, W. Han,

X. Li, Ph. D. , C. Benjamin Ma, M. D. , T. M. Link, M. D. , D. -D

A pilot study of the reproducibility and validity of measuring knee subchondral bone density in the tibia D. Dore, BBiotech.(Hons.), C. Ding, M.D., G.

The association between hip bone marrow lesions and bone mineral density: a cross- sectional and longitudinal population-based study H. Ahedi, D. Aitken,

Bone loss at subchondral plate in knee osteoarthritis patients with hypertension and type 2 diabetes mellitus C.Y. Wen, Y. Chen, H.L. Tang, C.H. Yan,

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse S.S. Glasson, M.G. Chambers, W.B. Van.

Longitudinal evaluation of T1ρ and T2 spatial distribution in osteoarthritic and healthy medial knee cartilage J. Schooler, D. Kumar, L. Nardo, C. McCulloch,

Is the atrophic phenotype of tibiofemoral osteoarthritis associated with faster progression of disease? The MOST study M.D. Crema, D.T. Felson, A. Guermazi,

Preliminary study on diffraction enhanced radiographic imaging for a canine model of cartilage damage C. Muehleman, Ph.D., J. Li, M.D., Z. Zhong, Ph.D.

The factors associated with pain severity in patients with knee osteoarthritis vary according to the radiographic disease severity: a cross-sectional.

Osteoarthritis and Cartilage

MRI in individuals with symptomatic knee osteoarthritis illustrating the structural abnormalities that discriminate symptomatic knee osteoarthritis best.

Abnormalities identified in the knees of asymptomatic volunteers using peripheral magnetic resonance imaging K.A. Beattie, B.Sc., P. Boulos, M.D., F.R.C.P.

Osteoarthritis year 2012 in review: imaging

Association between bone marrow lesions detected by magnetic resonance imaging and knee pain in community residents in Korea I.J. Kim, D.H. Kim, J.Y.

Quantifying biochemical changes in the cartilage matrix in osteoarthritic knee after hyaluronic acid injection using quantitative MR techniques A.R.

Cross-sectional and longitudinal associations between serum inflammatory cytokines and knee bone marrow lesions in patients with knee osteoarthritis

Presentation transcript:

Bone marrow lesions, subchondral bone cysts and subchondral bone attrition are associated with histological synovitis in patients with end-stage knee osteoarthritis: a cross-sectional study A. Yusup, H. Kaneko, L. Liu, L. Ning, R. Sadatsuki, S. Hada, K. Kamagata, M. Kinoshita, I. Futami, Y. Shimura, M. Tsuchiya, Y. Saita, Y. Takazawa, H. Ikeda, S. Aoki, K. Kaneko, M. Ishijima Osteoarthritis and Cartilage Volume 23, Issue 11, Pages 1858-1864 (November 2015) DOI: 10.1016/j.joca.2015.05.017 Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Association between the HSS and the BML score (A), SBC score (B) and SBA score (C) in patients with end-stage knee OA receiving TKA. The sagittal T2-weighted MR image (D, E and F) and the histological sections (G, H and I) of the three representative cases (J, K and L, respectively) those showed the presence of BML, SBC and SBA. J: Cartilage loss: grade 6 in MFc (arrow with head) and MTc, grade 5 in MFa and MTa, grade 4 in MFp and MTp, BML: grade 3 in MTa, grade 2 in MFc (arrow head), SBC: grade 1 in MFc (thin arrow), SBA: grade 1 in MTc (thick arrow), osteophyte: grade 7 in MFa (open arrow head), grade 5 in MFp, MTa and MTp, meniscus: grade 4 in the medial meniscus (open arrow). K: Cartilage loss: grade 6 in MFa, MFc, MTa and MTc, grade 5 in MFp (arrow with head) and MTp, BML: grade 3 in MFa, MFc (arrow head), MTa and MTc, grade 2 in MTp, SBC: grade 1 in MFa and MFc (thin arrow), SBA: grade 2 in MTc (thick arrow), osteophyte: grade 7 in MFa (open arrow head) and MFp, grade 6 in MTa, grade 5 in MTp, meniscus: grade 3 in the medial meniscus (open arrow), effusion: grade 1 (star). L: Cartilage loss: grade 6 in MFc (arrow with head), MFp and MTc, grade 4 in MFa and MTa, BML: grade 3 in MFa, MFc (arrow head), MFp, MTa, MTc and MTp, SBC: grade 3 in MFc (thin arrow), grade 2 in MFp, SBA: grade 3 in MFc and MTc (thick arrow), osteophyte: grade 4 in MTa (open arrow head) and MTp, grade 2 in MFa, meniscus: grade 3 in the medial meniscus (open arrow), effusion: grade 3 (star). MF: medial femoral plateau, MT: medial tibial plateau, a: anterior, c: central, p: posterior. Osteoarthritis and Cartilage 2015 23, 1858-1864DOI: (10.1016/j.joca.2015.05.017) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions