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Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity  J.P.

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Presentation on theme: "Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity  J.P."— Presentation transcript:

1 Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity  J.P. Moodie, K.S. Stok, R. Müller, T.L. Vincent, S.J. Shefelbine  Osteoarthritis and Cartilage  Volume 19, Issue 2, Pages (February 2011) DOI: /j.joca Copyright © Terms and Conditions

2 Fig. 1 A) 3D reconstruction of a tibial plateau, with ROI indicated. (B) 3D reconstruction of lateral ROI. (C) Subchondral bone plate ROI. (D) Trabecular bone ROI. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © Terms and Conditions

3 Fig. 2 Mean AP compliance curve for all contralateral (left) and DMM (right) legs. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © Terms and Conditions

4 Fig. 3 3D bone reconstructions and corresponding sagittal tomograms of tibial heads from a mouse 8 weeks after DMM surgery. (A) Contralateral (left) tibia. (B) DMM (right) tibia. (1) Indicates region of bone loss, (2) indicates bone growth. (C) and (D) μCT sagittal tomograms from A and B respectively, approximate location indicated by dashed line. Posterior subchondral bone loss is evident and extends beyond the growth plate, distal to the region of bone loss, bone remodelling is evident. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © Terms and Conditions

5 Fig. 4 μCT reconstructions of tibial heads, medial plateau in foreground. (1) Indicates region of bone loss, (2). indicates bone growth. (A) Contralateral (left) leg 4 weeks after surgery. (B) DMM (right) leg 4 weeks after surgery, significant bone growth can be seen on the posterior of the tibial head. (C) DMM (right) leg 4 weeks after surgery, extensive bone loss on the medial posterior plateau. (D) DMM (right) leg 8 weeks after surgery, minimal posterior bone loss but growth on anterior and medial aspect. (E) DMM (right) leg 8 weeks after surgery, extensive anterior bone formation. (F) DMM (right) leg 8 weeks after surgery, characteristic posterior bone loss and bone growth on posterior medial plateau. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © Terms and Conditions

6 Fig. 5 CSLM 3D cartilage thickness reconstructions from a mouse 8 weeks after DMM surgery superimposed on μCT reconstruction of bone. (A) Tibial cartilage from contralateral (left) leg. (B) Tibial cartilage from DMM (right) leg. Characteristic region of cartilage loss is visible on the posterior aspect of the medial plateau and corresponds with regions of bone loss. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © Terms and Conditions

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