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Joint loading and proximal tibia subchondral trabecular bone microarchitecture differ with walking gait patterns in end-stage knee osteoarthritis  B.C.

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Presentation on theme: "Joint loading and proximal tibia subchondral trabecular bone microarchitecture differ with walking gait patterns in end-stage knee osteoarthritis  B.C."— Presentation transcript:

1 Joint loading and proximal tibia subchondral trabecular bone microarchitecture differ with walking gait patterns in end-stage knee osteoarthritis  B.C. Roberts, L.B. Solomon, G. Mercer, K.J. Reynolds, D. Thewlis, E. Perilli  Osteoarthritis and Cartilage  Volume 25, Issue 10, Pages (October 2017) DOI: /j.joca Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

2 Fig. 1 (a) 3D micro-CT image of an excised tibial plateau from a right knee (view from top). The ellipses defining the medial and lateral tibial condyles are shown (dashed lines), containing the location of the four subvolumes of interest (VOIs, two per condyle as indicated by red circles) in the AM, AL, PM and PL compartments; (b) 2D coronal micro-CT cross-section image of the tibial plateau with medial and lateral boundaries of the ellipses indicated by red lines. The location of the AM and AL VOIs, relevant to the STB, are indicated. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

3 Fig. 2 Average 3D knee moment curves and standard deviation (shaded area, pink: biphasic, blue: flexor, yellow: counter-rotators) for each gait subgroup in knee OA. Statistically significant differences (P < 0.05, Bonferroni-corrected Mann–Whitney U test) in peak knee moments among subgroups are indicated: B = compared with biphasic, F = compared with flexors, C = compared with counter-rotators. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

4 Fig. 3 Stacked bar-graphs indicating tibiofemoral compartment-specific (medial and lateral) OARSI Atlas scores for osteophytes, JSN and presence of bone sclerosis in the knee OA gait subgroups. Numbers in bars indicate number of patients. For osteophytes and JSN, colours (from blue to red) indicate worsening disease severity. For bone sclerosis, blue: bone sclerosis absent, red: bone sclerosis present. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

5 Fig. 4 Average knee flexion angle curves and standard deviation (shaded area, pink: biphasic, blue: flexor, yellow: counter-rotators) for each gait subgroup in knee OA. Statistically significant differences (P < 0.05, Bonferroni-corrected Mann–Whitney U test) in knee excursion during loading response among subgroups are indicated: B = compared with biphasic. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

6 Fig. 5 Bar graphs reporting average values and standard deviations (error bars) of (top) subregional STB microarchitecture, and (bottom) bone BV/TV ratios among subregions, for the gait subgroups in knee OA. Statistically significant differences between gait subgroups are indicated by brackets (P < 0.05, Bonferroni-corrected Mann–Whitney U test). The horizontal dashed line indicates unity in the BV/TV ratios among subregions. A: anterior; P: posterior; M: medial; L: lateral. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions


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