Traumatic Wound Dehiscence After Corneal Keratoplasty Patrick F Tzelikis, MD, PhD, Wilson T Hida, MD, PhD The authors of this poster have no financial interest to disclosure Protocolo Hospital Oftalmológico de Brasília – HOB Brasilia – DF - Brazil

Introduction Any globe is susceptible to rupture and will do so at its weakest point if subject to enough strength. Keratoplasty exposes patients to a higher risk of globe rupture because the surgical wound may never regain the strength and stability of an intact cornea.

Purpose To assess the patient characteristics, risk factors, outcomes, and treatment of wound dehiscence (WD) in patients after corneal keratoplasty.

Methods This study is a retrospective, noncomparative, interventional case series In this study, the authors present their experience of 11 cases of traumatic graft dehiscence after penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK) seen at the Brasilia Ophthalmologic Hospital (HOB), Brasilia, Brazil, between January 2005 and December 2013.

Results Our hospital performed 471 keratoplasties during the 8-year study period, and eleven eyes (2.33%) in this group presented with globe rupture. The type of keratoplasty was penetrating keratoplasty (PK) in 5 eyes (45.5%), and deep anterior lamellar keratoplasty (DALK) in 6 eyes (54.5%). All eyes were phakic before the trauma.

Results The study included 11 eyes of 11 patients, 8 (72.7%) were men and 3 were women. The mean patient age at the time of rupture was 31.1 years ± 8.81 (SD) (range 17 to 44 years). Median interval between keratoplasty and globe rupture was 12.82 months (range, 3 months to 33 months). The mean follow-up time after the repair surgery was 4.36 ± 2.5 years (range, 1-8 years). The most common indication for the original graft was keratoconus.

Results Table 1 shows the demographic data for our eleven patients with globe rupture.

Results Table 1 shows the demographic data for our eleven patients with globe rupture. Abbreviations: yrs: years; M: male; F: female; KCN: keratoconus; HSK: herpes simplex keratitis; PK: penetrating keratoplasty; DALK: deep anterior lamellar keratoplasty; NPL: no light perception; RD: retinal detachment.

Results Best-corrected visual acuity of patients at the last visit before trauma ranged between 20/20 to 20/300 (mean, 20/60). At the final visit after the repair surgery the mean BCVA was 20/160 (range, 20/50 to no light perception). The difference between the mean BCVA at the last visit before trauma and the last visit after the repair surgery was not found to be statistically significant (P=0.15). At the last visit, 8 grafts (72.7%) were clear, 2 (18.2%) experienced graft failure and the eye subsequently underwent repeat penetrating keratoplasty, and 1 eye (9.1%) developed phthisis bulbi.

Conclusion In summary, this study found that the risk of traumatic corneal graft rupture after keratoplasty, even years after surgery, is significant and might cause a bad visual outcome. In future, it is expected that the use of nonpenetrating or small-incision graft techniques, such as deep anterior lamellar keratoplasty for management of stromal corneal pathologies and posterior lamellar keratoplasty for endothelium dysfunction, offer a further advantage of reducing the rate of graft dehiscence and the severity of the consequences.