Practical Challenges in Obesity: Is It Possible to Maintain Weight Loss?

Introduction/Overview

The Obesogenic Environment

The Ready Availability of Foods That Promote Obesity

Epigenetic Changes: Causes or Consequences of Obesity?

"Fidgeting“* Can Inhibit Weight Gain (at Least in Some Individuals)

Gut Microbiota and Obesity

The Conversation: Finding Out Why a Patient Overeats May Help to Target the Treatment

Mechanisms of Food Intake Regulation

Gut Hormone Changes Persistently Oppose Diet-Induced Weight Loss

Fat Deposition May Be Determinative of Cardiometabolically Risky Obesity

Obesity as a Risk Factor for (and Multiplier of) a Range of Comorbid Conditions

Weight Loss Is a Challenge Because, Physiologically, It Is Perceived as a Dysfunction

Obesity: Imbalance of Energy Regulation

Factors Associated With Long-Term Weight Loss Maintenance

“The Biggest Loser” and the Persistence of Metabolic Adaptation

Obesity Is a Serious Disease; It Needs to Be Treated Like a Serious Disease

Characteristics of More and Less Successful Weight Loss Losers After Bariatric Surgery

Weight Loss With Orlistat: 2 Years’ Data

Weight Loss With Naltrexone/Bupropion: 78 Weeks

Early Treatment Response and Stopping Rules

SCALE Maintenance: Proportion of Patients Maintaining Run-In Weight Loss or Regaining ≥ 5% From Randomization to Week 56

Real-World Clinical Effectiveness of Liraglutide 3.0 mg

Summary and Conclusions

Abbreviations

Abbreviations (cont)