1. Clinical Review

2. Definition of Severe Asthma

3. Definition of Uncontrolled Asthma

4. Uncontrolled Asthma

5. Worldwide Asthma Overview

6. Severe Asthma Is Not a Rare Disease

7. Serious Consequences of Severe Asthma

8. Substantial Residual Disease Burden After Treatment Optimization

9. Emerging Asthma Phenotypes

10. Targets for Biologic Treatments of T2-Type Asthma

11. Blocking the Allergic Cascade by Omalizumab

12. Allergy in Patients With Severe Asthma

13. Effect of Omalizumab on Exacerbations

14. Omalizumab Reduces the Requirement for OCS

15. Pooled Analysis: Asthma-Related Emergency Visits

16. Omalizumab Improved Asthma-Related QoL

17. Overview of Real-World Studies of Omalizumab

18. International Consensus on Pediatric Asthma

19. Pediatric Study (France): Effect of Omalizumab

20. GINA-Based Treatment Steps

21. Conclusions

22. Abbreviations

23. Abbreviations (cont)