Tim Willinger, Richard A. Flavell Cell Stem Cell

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Presentation transcript:

ESCaping Rejection: A Step Forward for Embryonic-Stem-Cell-Based Regenerative Medicine Tim Willinger, Richard A. Flavell Cell Stem Cell Volume 14, Issue 1, Pages 3-4 (January 2014) DOI: 10.1016/j.stem.2013.12.003 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Protection of CTLA4-Ig/PD-L1 Knockin hESCs from Immune Rejection Parental hECS are rejected by human T cells in mice with a reconstituted human immune system (top). In contrast, hESC that constitutively express CTLA4-Ig and PD-L1, and differentiated cells derived from these engineered hESCs, escape rejection by creating a local immunosuppressive environment (bottom). Cell Stem Cell 2014 14, 3-4DOI: (10.1016/j.stem.2013.12.003) Copyright © 2014 Elsevier Inc. Terms and Conditions