The effect of montelukast, budesonide alone, and in combination on exercise-induced bronchoconstriction MyLinh Duong, MBBS, Reshma Amin, MD, Adrian J.

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Presentation transcript:

The effect of montelukast, budesonide alone, and in combination on exercise-induced bronchoconstriction MyLinh Duong, MBBS, Reshma Amin, MD, Adrian J. Baatjes, MSc, Fiona Kritzinger, MBChB, Ying Qi, MSc, Zahida Meghji, MSc, Wendy Lou, PhD, Hartmut Grasemann, PhD, Paul M. O'Byrne, MB, Padmaja Subbarao, MD Journal of Allergy and Clinical Immunology Volume 130, Issue 2, Pages 535-539.e3 (August 2012) DOI: 10.1016/j.jaci.2012.02.051 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Pre- and posttreatment values for maximal fall in FEV1 (maxFEV%) and area under the curve for FEV1 over 30 minutes (AUC-FEV0-30) for each treatment. B, Budesonide; B + M, combination therapy; M, montelukast; P, placebo. Changes following treatment compared with placebo at *P < .05 and **P ≤ .005. Journal of Allergy and Clinical Immunology 2012 130, 535-539.e3DOI: (10.1016/j.jaci.2012.02.051) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Flow diagram of study design. At the first screening visit, an exercise challenge was performed followed in 1 week by a second screening visit with an exercise challenge. Qualified subjects return the following day* for a methacholine and skin prick test and are randomized to the first treatment. Each treatment period was for 2 weeks with a pretreatment (PRE) and posttreatment (POST) visit and a washout of 4 to 6 weeks between treatment periods. Treatments were matching placebos, montelukast 5/10 mg, budesonide 400 μg, or montelukast + budesonide. Journal of Allergy and Clinical Immunology 2012 130, 535-539.e3DOI: (10.1016/j.jaci.2012.02.051) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Flowchart of enrolled subjects. Journal of Allergy and Clinical Immunology 2012 130, 535-539.e3DOI: (10.1016/j.jaci.2012.02.051) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions