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Inhibitory effect of a leukotriene receptor antagonist (montelukast) on neurokinin a- induced bronchoconstriction  Nunzio Crimi, MD, Corrado Pagano, MD,

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Presentation on theme: "Inhibitory effect of a leukotriene receptor antagonist (montelukast) on neurokinin a- induced bronchoconstriction  Nunzio Crimi, MD, Corrado Pagano, MD,"— Presentation transcript:

1 Inhibitory effect of a leukotriene receptor antagonist (montelukast) on neurokinin a- induced bronchoconstriction  Nunzio Crimi, MD, Corrado Pagano, MD, Filippo Palermo, BSc, Claudio Mastruzzo, MD, PhD, Gaetano Prosperini, MD, Maria P. Pistorio, BSc, Carlo Vancheri, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 111, Issue 4, Pages (April 2003) DOI: /mai Copyright © 2003 Mosby, Inc. Terms and Conditions

2 Fig. 1 Study design: a 2-phase, randomized, placebo-controlled, crossover study. In the first phase a concentration-response study was performed either with methacholine or NKA in the absence of any drug treatment. During the second phase, each subject recruited went through all possible combinations of drug administration and challenge procedures. R, Random; Meth, methacholine; M, montelukast; P, placebo. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

3 Fig. 2 Effect of montelukast (filled squares) compared with placebo (open triangles) on the concentration-response curves to inhaled NKA in 9 asthmatic subjects. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

4 Fig. 3 Mean values of the area under the concentration-response curve to inhaled NKA after placebo and montelukast treatment. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

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