Computer-aided quantification of focal cartilage lesions using MRI: Accuracy and initial arthroscopic comparison Keh-Yang Lee, Ph.D., Jeffrey N. Masi,

Slides:

Advertisements

Similar presentations

Anatomical alignment, but not goniometry, predicts femorotibial cartilage loss as well as mechanical alignment: data from the Osteoarthritis Initiative

Advertisements

X. I. Gu, P. E. Palacio-Mancheno, D. J. Leong, Y. A. Borisov, E

Validity and responsiveness of a new measure of knee osteophytes for osteoarthritis studies: data from the osteoarthritis initiative M. Hakky, M. Jarraya,

Novel optical imaging technique to determine the 3-D orientation of collagen fibers in cartilage: variable-incidence angle polarization-sensitive optical.

A. Guermazi, H. Alizai, M. D. Crema, S. Trattnig, R. R. Regatte, F. W

T1ρ relaxation time of the meniscus and its relationship with T1ρ of adjacent cartilage in knees with acute ACL injuries at 3T R.I. Bolbos, Ph.D., T.M.

Prevalence of labral tears and cartilage loss in patients with mechanical symptoms of the hip: evaluation using MR arthrography G. Neumann, M.D., A.D.

Functional cartilage MRI T2 mapping: evaluating the effect of age and training on knee cartilage response to running T.J. Mosher, Y. Liu, C.M. Torok

Imaging following acute knee trauma

2D and 3D MOCART scoring systems assessed by 9

Considerations in measuring cartilage thickness using MRI: factors influencing reproducibility and accuracy S. Koo, M.S., G.E. Gold, M.D., T.P. Andriacchi,

Cartilage Thickness, Denudation and Kl Grade: A Study of Medial Femorotibial Joints in 8,890 Knees from the Osteoarthritis Initiative G. Guillard, G.R.

Osteoporosis increases the severity of cartilage damage in an experimental model of osteoarthritis in rabbits E. Calvo, M.D., S. Castañeda, M.D., R.

Anisotropy of collagen fibre alignment in bovine cartilage: comparison of polarised light microscopy and spatially resolved diffusion-tensor measurements

Cartilage and meniscal T2 relaxation time as non-invasive biomarker for knee osteoarthritis and cartilage repair procedures T. Baum, G.B. Joseph, D.C.

T1ρ and T2 relaxation times predict progression of knee osteoarthritis

An MRI derived articular cartilage visualization framework

MRI of articular cartilage in OA: novel pulse sequences and compositional/functional markers Garry E. Gold, Deborah Burstein, Bernard Dardzinski, Phillip.

Intraoperative validation of quantitative T2 mapping in patients with articular cartilage lesions of the knee S.T. Soellner, A. Goldmann, D. Muelheims,

Three-dimensional MRI-based statistical shape model and application to a cohort of knees with acute ACL injury V. Pedoia, D.A. Lansdown, M. Zaid, C.E.

A novel fast knee cartilage segmentation technique for T2 measurements at MR imaging – data from the Osteoarthritis Initiative C. Stehling, T. Baum,

Relationship between trabecular bone structure and articular cartilage morphology and relaxation times in early OA of the knee joint using parallel MRI.

Evaluation of translation in the normal and dysplastic hip using three-dimensional magnetic resonance imaging and voxel-based registration K. Akiyama,

Measurement accuracy of focal cartilage defects from MRI and correlation of MRI graded lesions with histology: a preliminary study Chris A McGibbon,

M. C. Gallo, C. Wyatt, V. Pedoia, D. Kumar, S. Lee, L. Nardo, T. M

Cross-sectional DXA and MR measures of tibial periarticular bone associate with radiographic knee osteoarthritis severity G.H. Lo, A.M. Tassinari, J.B.

Quantitatively-measured bone marrow lesions in the patellofemoral joint: distribution and association with pain C. Ratzlaff, R. Russell, J. Duryea Osteoarthritis.

Differences between X-ray and MRI-determined knee cartilage thickness in weight- bearing and non-weight-bearing conditions M. Marsh, R.B. Souza, B.T.

Cluster analysis of quantitative MRI T2 and T1ρ relaxation times of cartilage identifies differences between healthy and ACL-injured individuals at 3T

Regional variations of collagen orientation in normal and diseased articular cartilage and subchondral bone determined using small angle X-ray scattering.

Volumetric and semiquantitative assessment of MRI-detected subchondral bone marrow lesions in knee osteoarthritis: a comparison of contrast-enhanced and.

B. Bittersohl, F. R. Miese, H. S. Hosalkar, M. Herten, G. Antoch, R

Effects of ACL interference screws on articular cartilage volume and thickness measurements with 1.5 T and 3 T MRI M.E. Bowers, B.S., G.A. Tung, M.D.,

Knee cartilage thickness measurements using MRI: a 4½-month longitudinal study in the meniscectomized guinea pig model of OA R. Bolbos, M.Sc., H. Benoit-Cattin,

Change in bone area does not correlate with cartilage loss over 12 months in individuals with knee OA: Data from the osteoarthritis initiative M.A. Bowes,

Comparison of load responsiveness of cartilage T1rho and T2 in porcine knee joints: an experimental loading MRI study H. Hamada, T. Nishii, S. Tamura,

Estimation of mechanical properties of articular cartilage with MRI – dGEMRIC, T2 and T1 imaging in different species with variable stages of maturation

P. Julkunen, J. Iivarinen, P. A. Brama, J. Arokoski, J. S. Jurvelin, H

P. -H. Tsai, M. -C. Chou, H. -S. Lee, C. -H. Lee, H. -W. Chung, Y. -C

Automatic morphometric cartilage quantification in the medial tibial plateau from MRI for osteoarthritis grading E.B. Dam, Ph.D., J. Folkesson, M.Sc.,

Articular cartilage MR imaging and thickness mapping of a loaded knee joint before and after meniscectomy Y. Song, M.S., J.M. Greve, M.S., D.R. Carter,

T. Nozaki, Y. Kaneko, H. Yu, K. Kaneshiro, R. Schwarzkopf, T. Hara, H

M. R. Doschak, Ph. D. , J. M. LaMothe, Ph. D. , D. M. L. Cooper, B. Sc

Evaluations of radiographic joint space – do they adequately predict cartilage conditions in the patellofemoral joint of the patients undergoing total.

Quantitative MR T2 measurement of articular cartilage to assess the treatment effect of intra-articular hyaluronic acid injection on experimental osteoarthritis.

M. Wang, A. Radjenovic, T. W. Stapleton, R. Venkatesh, S. Williams, E

Pre-radiographic osteoarthritic changes are highly prevalent in the medial patella and medial posterior femur in older persons: Framingham OA study D.

Anatomical alignment, but not goniometry, predicts femorotibial cartilage loss as well as mechanical alignment: data from the Osteoarthritis Initiative

Joint space narrowing and Kellgren–Lawrence progression in knee osteoarthritis: an analytic literature synthesis P.S. Emrani, B.S., J.N. Katz, M.D.,

Dr J. H. Naish, Ph. D. , Dr E. Xanthopoulos, Ph. D. , Dr C. E

The relation of femoral notch stenosis to ACL tears in persons with knee osteoarthritis V. Stein, L. Li, A. Guermazi, Y. Zhang, C. Kent Kwoh, C.B. Eaton,

F.W. Roemer, M.D. Osteoarthritis and Cartilage

Classification of graft hypertrophy after autologous chondrocyte implantation of full- thickness chondral defects in the knee P.C. Kreuz, M.D., M. Steinwachs,

K. E. Keenan, T. F. Besier, J. M. Pauly, E. Han, J. Rosenberg, R. L

Comparison of BLOKS and WORMS scoring systems part I

Assessment of clinical and MRI outcomes after mesenchymal stem cell implantation in patients with knee osteoarthritis: a prospective study Y.S. Kim,

A novel method for assessing signal intensity within infrapatellar fat pad on MR images in patients with knee osteoarthritis M. Lu, Z. Chen, W. Han,

MRI-derived T2 relaxation times and cartilage morphometry of the tibio-femoral joint in subjects with and without osteoarthritis during a 1-year follow-up

Templates of the cartilage layers of the patellofemoral joint and their use in the assessment of osteoarthritic cartilage damage Z.A Cohen, Ph.D., V.C.

X. Li, Ph. D. , C. Benjamin Ma, M. D. , T. M. Link, M. D. , D. -D

Surface roughness and thickness analysis of contrast-enhanced articular cartilage using mesh parameterization T. Maerz, M.D. Newton, H.W.T. Matthew,

Computed tomography topographic mapping of subchondral density (CT-TOMASD) in osteoarthritic and normal knees: methodological development and preliminary.

3D modelling of the hip joint from clinical imaging data

Magnitude and regional distribution of cartilage loss associated with grades of joint space narrowing in radiographic osteoarthritis – data from the Osteoarthritis.

Longitudinal evaluation of T1ρ and T2 spatial distribution in osteoarthritic and healthy medial knee cartilage J. Schooler, D. Kumar, L. Nardo, C. McCulloch,

Correlation between the MR T2 value at 4

Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen.

Preliminary study on diffraction enhanced radiographic imaging for a canine model of cartilage damage C. Muehleman, Ph.D., J. Li, M.D., Z. Zhong, Ph.D.

A pilot, two-year longitudinal study of the interrelationship between trabecular bone and articular cartilage in the osteoarthritic knee Gabrielle Blumenkrantz,

M. E. Bowers, B. S. , N. Trinh, M. S. , G. A. Tung, M. D. , F. A. C. R

Presentation transcript:

Computer-aided quantification of focal cartilage lesions using MRI: Accuracy and initial arthroscopic comparison Keh-Yang Lee, Ph.D., Jeffrey N. Masi, B.S., Christian A. Sell, B.S., Robert Schier, B.S., Thomas M. Link, M.D., Lynne S. Steinbach, M.D., Marc Safran, M.D., Benjamin Ma, M.D., Sharmila Majumdar, Ph.D. Osteoarthritis and Cartilage Volume 13, Issue 8, Pages 728-737 (August 2005) DOI: 10.1016/j.joca.2005.03.007 Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 1 A porcine femur is shown in the setup of surgical lesion creation. The shaft of the femur is mounted on a drill press, and with a ball joint (white arrow) the bit is oriented perpendicular to the cartilage surface. Osteoarthritis and Cartilage 2005 13, 728-737DOI: (10.1016/j.joca.2005.03.007) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 2 Two lesions are shown created on the trochlea of a femur and two other lesions are created on the condyles. Osteoarthritis and Cartilage 2005 13, 728-737DOI: (10.1016/j.joca.2005.03.007) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 3 The dimensions of lesions are measured using a caliper with resolution of 0.1mm in the following format: (1) for both types of lesions, one diameter measurement is made on the sagittal (in-plane) plane, and another diameter measurement is made along latero-medial (slice) direction, (2) for a cylindrical lesion, eight depth measurements are performed equally spaced along the wall of the lesion, (3) for a conical lesion, one depth measurement is taken at the center of the lesion. Osteoarthritis and Cartilage 2005 13, 728-737DOI: (10.1016/j.joca.2005.03.007) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 4 (a) A diagram that helps demonstrate the lesion boundary search of GPM. C: center of the lesion; θ0: initial angle; B1: the point which has the lowest curvature and a positive gradient at angle θ0; R1: the radius from C to B1; Δθ: angular step; B2: the point which has the lowest curvature and a positive gradient at angle θ0+Δθ. (b) Illustration of a sample lesion. Osteoarthritis and Cartilage 2005 13, 728-737DOI: (10.1016/j.joca.2005.03.007) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 5 Two conical lesions on a porcine knee are shown in (a). (b) An MR slice shows the right lesion (SPGR sequence with TR of 30ms, TE of 3.1ms, flip angle of 30° and 0.23×0.23×1.5mm3 voxel size). Both lesions are grade 4 for full cartilage loss. (c) A cartilage map is shown on the bone as the lesion boundaries defined by GPM are displayed in red dash lines. The manual measurements and the assessments by GPM are listed in Table I. Osteoarthritis and Cartilage 2005 13, 728-737DOI: (10.1016/j.joca.2005.03.007) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 6 (a) Normal thickness, (b) focal thickness, (c) lesion depth, (d) xy-diameter, (e) z-diameter, and (f) lesion area obtained from 1.5T data are plotted with those obtained from 3T data in the comparison experiment. In each figure, a regression line is also plotted as a solid line. A statistical analysis shows that four properties obtained from 1.5T and 3T scans correlate well (R=0.92 for normal thickness, R=0.92 for focal thickness, R=0.65 for depth, R=0.88 for xy-diameter, R=0.64 for z-diameter, and R=0.92 for area). Osteoarthritis and Cartilage 2005 13, 728-737DOI: (10.1016/j.joca.2005.03.007) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 7 (a) A representative arthroscopic picture, (b) a cartilage map and (c) a representative MR slices of Patient 3. A 1cm focal chondral lesion on the trochlea is reported in an arthroscopic exam. By using GPM, a focal lesion is defined on trochlea with an estimated area of 53mm2. Based on the SPGR MR images, the trochlea of the patient are focal/grade 3. The units on spatial coordinates and on color scale are both millimeters. Osteoarthritis and Cartilage 2005 13, 728-737DOI: (10.1016/j.joca.2005.03.007) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions